PMID: 589870Nov 1, 1977

Sensitivity changes in guinea-pig atria and ileum following subacute administration of dyflos

Clinical and Experimental Pharmacology & Physiology
F Mitchelson, R A O'Shea


1. Subacute administration of dyflos to guinea-pigs (1.2 mg/kg, s.c., daily for 10 days) led to the development of subsensitivity to carbachol in the ileum but not in the electrically stimulated left atrium. 2. Atria from dyflos-pretreated animals became supersensitive to acetylcholine but the ileum became subsensitive to this agonist despite marked inhibition of cholinesterases. The degree of subsensitivity was less than that for carbachol. 3. Subsensitivity also developed to histamine and was of a similar order to that observed for carbachol supporting the suggestion that subsensitivity is a nonspecific post-receptor mechanism. 4. Other changes which occurred in the ileum, together with the increase in the EC50 value to agonists were an increase in tissue mass, an increase in the slope of the concentration-response curve to agonists and an increase in the maximal response to agonists.


Jan 1, 1975·The Journal of Physiology·G D HirstH C McKirdy
May 1, 1969·British Journal of Pharmacology·F HobbigerM J RAND
Oct 1, 1971·The Journal of Pharmacy and Pharmacology·A R Pomeroy, C Raper
Nov 1, 1952·Proceedings of the Society for Experimental Biology and Medicine·J A RIDERJ M COON
Jun 1, 1963·British Journal of Pharmacology and Chemotherapy·J HARRY
Dec 1, 1963·British Journal of Pharmacology and Chemotherapy·G BROWNLEE, J HARRY
Feb 1, 1965·British Journal of Pharmacology and Chemotherapy·S HUKOVICS VANOV

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