Sensitivity of bronchial responsiveness measurements in young infants

Chest
Lotte LolandH Bisgaard

Abstract

There is limited evidence on the preferred methods for evaluating lung function in infancy. The objective of this study was to compare sensitivity and repeatability of indexes of lung function in young infants during induced airway obstruction. The study population consisted of 402 infants (median age, 6 weeks). Forced flow-volume measurements were obtained by the raised volume rapid thoracoabdominal compression technique and were compared with indexes of tidal breathing, measurements of transcutaneous oxygen (Ptco(2)), and auscultation during methacholine challenge testing. Ptco(2) was the most sensitive parameter to detect increasing airway obstruction during methacholine challenge, followed by forced expiratory volume at 0.5 s (FEV(0.5)). Both were superior to other indexes of forced spirometry as well as tidal breathing indexes and auscultation. Coefficients of variations for Ptco(2) and FEV(0.5) were 4% and 7%, respectively. Ptco(2) and FEV(0.5) are the most sensitive parameters for measurement of bronchial responsiveness in young infants. Measurements of baseline lung function should preferably be made using FEV(0.5.) Measurements of bronchial responsiveness are best assessed using Ptco(2), which may be performed in nonse...Continue Reading

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Citations

Oct 12, 2007·The New England Journal of Medicine·Hans BisgaardChristian Bressen Pipper
May 12, 2006·The New England Journal of Medicine·Hans BisgaardFrederik Buchvald
Nov 26, 2008·American Journal of Respiratory and Critical Care Medicine·Hans BisgaardHakon Hakonarsson
Mar 20, 2010·American Journal of Respiratory and Critical Care Medicine·Bo L K ChawesHans Bisgaard
Oct 5, 2013·American Journal of Respiratory and Critical Care Medicine·Nadja H VissingHans Bisgaard
Jun 21, 2012·The Journal of Allergy and Clinical Immunology·Bo L K ChawesHans Bisgaard
Mar 14, 2009·The Journal of Allergy and Clinical Immunology·Sean Yemen, Benjamin Gaston
Jan 21, 2009·The Journal of Allergy and Clinical Immunology·Hans BisgaardChristian B Pipper
Oct 25, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E Kreiner-MøllerK Bønnelykke
Oct 23, 2010·Pediatric Pulmonology·L Pekka MalmbergMika J Mäkelä
Dec 24, 2009·Indoor Air·O Raaschou-NielsenH Bisgaard
Jan 13, 2015·The Journal of Allergy and Clinical Immunology·Bo L K ChawesHans Bisgaard
May 27, 2014·The Journal of Allergy and Clinical Immunology·Eskil Kreiner-MøllerKlaus Bønnelykke
Sep 15, 2016·American Journal of Respiratory and Critical Care Medicine·Jakob StokholmHans Bisgaard
Mar 31, 2012·American Journal of Respiratory and Critical Care Medicine·Hans BisgaardKlaus Bønnelykke

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