PMID: 9422695Jan 31, 1998Paper

Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations

Science
P De Koninck, H Schulman

Abstract

The transduction of many cellular stimuli results in oscillations in the intracellular concentration of calcium ions (Ca2+). Although information is thought to be encoded in the frequency of such oscillations, no frequency decoder has been identified. Rapid superfusion of immobilized Ca2+- and calmodulin-dependent protein kinase II (CaM kinase II) in vitro showed that the enzyme can decode the frequency of Ca2+ spikes into distinct amounts of kinase activity. The frequency response of CaM kinase II was modulated by several factors, including the amplitude and duration of individual spikes as well as the subunit composition and previous state of activation of the kinase. These features should provide specificity in the activation of this multifunctional enzyme by distinct cellular stimuli and may underlie its pivotal role in activity-dependent forms of synaptic plasticity.

References

Jan 1, 1992·Annual Review of Biochemistry·P I Hanson, H Schulman
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S S Molloy, M B Kennedy
Jan 1, 1991·Annual Review of Biophysics and Biophysical Chemistry·T Meyer, L Stryer
Jan 1, 1990·Neuroscience Research. Supplement : the Official Journal of the Japan Neuroscience Society·J H Skene
Nov 1, 1990·The Journal of Cell Biology·C BaitingerR A Steinhardt
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J Lisman
Oct 1, 1994·Trends in Neurosciences·J Lisman
Sep 15, 1995·The Journal of Biological Chemistry·K Luby-PhelpsD Won
Jan 1, 1995·Advances in Second Messenger and Phosphoprotein Research·T R Soderling
Jan 1, 1995·Annual Review of Physiology·A P Braun, H Schulman
Jan 27, 1995·Cell·D E Clapham
Jan 28, 1993·Nature·M J Berridge
Dec 1, 1995·Current Biology : CB·K DeisserothR W Tsien
Apr 24, 1997·Nature·M J Berridge

❮ Previous
Next ❯

Citations

May 20, 1999·The Journal of Comparative Neurology·L Maler, M T Hincke
Sep 30, 1999·Microscopy Research and Technique·M Whitaker
Sep 30, 1999·Microscopy Research and Technique·G E Hardingham, H Bading
Oct 20, 1998·Journal of Neurobiology·M J O'DonovanP Wenner
Oct 20, 1998·Journal of Neurobiology·S Finkbeiner, M E Greenberg
Oct 20, 1998·Journal of Neurobiology·W J Moody
Oct 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Dupont, A Goldbeter
Aug 17, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N C SpitzerT M Gomez
Mar 14, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Christopher Rongo
Jul 13, 2002·Journal of Neurobiology·Demian ParkLeslie C Griffith
Aug 25, 2004·Neurotoxicity Research·Martín CammarotaN Izquierdo
May 9, 2008·Cellular and Molecular Life Sciences : CMLS·M T Swulius, M N Waxham
Nov 23, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Chad E GrueterMark E Anderson
Jun 19, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Julie Bossuyt, Donald M Bers
Jun 15, 2010·The Journal of Membrane Biology·Joanne E MillershipJason I E Bruce
Nov 1, 2007·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Stefan ClemensPaul S Katz
Oct 25, 2007·Pflügers Archiv : European journal of physiology·Lavanya BalasubramanianKay-Pong Yip
Aug 10, 2006·Cell and Tissue Research·Christian LohrDaniela Hirnet
Sep 21, 2010·Lasers in Medical Science·Luigi BarattoSilvano Traverso
Nov 4, 2006·Biomechanics and Modeling in Mechanobiology·Lindsay M GodinSeth W Donahue
Dec 1, 2005·Journal of Biological Physics·Nadiya A Brazhe UlyanovaGeorgy V Maksimov
Jan 17, 2008·Theory in Biosciences = Theorie in Den Biowissenschaften·Beate KnokeStefan Schuster
Jul 17, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Arthur D Conigrave, Donald T Ward
Feb 12, 2004·Biophysical Chemistry·Ann Zahle LarsenUrsula Kummer
Mar 12, 2004·Progress in Neurobiology·P V Nguyen, N H Woo
Jul 16, 2013·Progress in Neurobiology·Marijke De BockLuc Leybaert
May 4, 2005·Trends in Neurosciences·Guo-Qiang Bi, Jonathan Rubin
Dec 5, 1998·Biochimica Et Biophysica Acta·P J Cullen
Oct 3, 2002·Biochemical and Biophysical Research Communications·Arata UemuraTatsuaki Matsubara
Jun 8, 1999·Chemistry and Physics of Lipids·R F IrvineM J Schell
Jun 12, 2003·Developmental Biology·Styliani MarkoulakiTom Ducibella
Oct 24, 2003·Cell Calcium·Jason I E BruceDavid I Yule
Oct 24, 2003·Cell Calcium·Geneviève DupontPaul De Koninck

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.