Sensitivity of fatty acid desaturation and elongation to plasma zinc concentration: a randomised controlled trial in Beninese children

The British Journal of Nutrition
Tsitsi ChimhashuMichael B Zimmermann

Abstract

Zn status may affect fatty acid (FA) metabolism because it acts as a cofactor in FA desaturase and elongase enzymes. Zn supplementation affects the FA desaturases of Zn-deficient rats, but whether this occurs in humans is unclear. We evaluated the associations between baseline plasma Zn (PZn) concentration and plasma total phospholipid FA composition, as well as the effect of daily consumption of Zn-fortified water on FA status in Beninese children. A 20-week, double-blind randomised controlled trial was conducted in 186 school age children. The children were randomly assigned to receive a daily portion of Zn-fortified, filtered water delivering on average 2·8 mg Zn/d or non-fortified filtered water. Plasma total phospholipid FA composition was determined using capillary GLC and PZn concentrations by atomic absorption spectrometry. At baseline, PZn correlated positively with dihomo-γ-linolenic acid (DGLA, r 0·182; P=0·024) and the DGLA:linoleic acid (LA) ratio (r 0·293; P<0·000), and negatively with LA (r -0·211; P=0·009) and the arachidonic acid:DGLA ratio (r -0·170; P=0·036). With the intervention, Zn fortification increased nervonic acid (B: 0·109; 95 % CI 0·001, 0·218) in all children (n 186) and more so in children who wer...Continue Reading

References

Mar 1, 1979·The Journal of Nutrition·W J BettgerB L O'Dell
Sep 1, 1981·Medical Hypotheses·D F Horrobin
Dec 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·S C CunnaneM S Manku
Jan 1, 1995·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·P FaureA M Roussel
Oct 1, 1993·The American Journal of Clinical Nutrition·L SianP V Fennessey
Jan 1, 1993·Physiological Reviews·B L Vallee, K H Falchuk
Sep 10, 1998·The Journal of Nutrition·Y Y Fan, R S Chapkin
Jun 11, 2004·Annual Review of Nutrition·Manabu T Nakamura, Takayuki Y Nara
Jun 24, 2004·Nutrition·Henry C Lukaski
Aug 11, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ella N SmitE Rudy Boersma
Nov 30, 2005·The Proceedings of the Nutrition Society·David I ThurnhamArjan De Wagt
Jan 13, 2006·Current Opinion in Lipidology·Ana Baylin, Hannia Campos
Sep 12, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Allison M HodgeGraham G Giles
Dec 22, 2006·The Journal of Nutrition·Leland V MillerK Michael Hambidge
Nov 9, 2007·Food and Nutrition Bulletin·Sonja Y HessKenneth H Brown
May 8, 2009·The American Journal of Clinical Nutrition·Nicola M LoweTamás Decsi
Sep 19, 2009·Methods in Molecular Biology·Donald B Jump
Nov 10, 2009·Behavior Research Methods·Franz FaulAlbert-Georg Lang
Feb 4, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Bhumika Tripathi, Kalpana Platel
Jul 7, 2011·International Journal of Molecular Sciences·María S GimenezNidia N Gomez
Jun 1, 2009·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Mohamed Attia AttiaOsama A El-Agamy
Dec 26, 2012·Journal of Inorganic Biochemistry·George VardatsikosAshok K Srivastava
May 25, 2013·Annals of Nutrition & Metabolism·Jai K DasZulfiqar A Bhutta
Jul 24, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Vinay Prasad
Dec 18, 2013·Annals of the New York Academy of Sciences·Diego MorettiKlaus Kraemer
Jul 17, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Philip C Calder
Oct 16, 2015·The American Journal of Clinical Nutrition·Valeria GalettiDiego Moretti
Mar 11, 2016·The Journal of Nutrition·Janet C KingDaniel J Raiten

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Citations

Jan 25, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Frank Comhaire, Wim Decleer
Sep 6, 2018·The Journal of Nutrition·Janet C King
Jun 14, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·María Catalina HernándezManuel Ruz
Jun 3, 2021·Nutrients·Agnieszka StawarskaBarbara Bobrowska-Korczak

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