Sensitivity of femoral strain calculations to anatomical scaling errors in musculoskeletal models of movement

Journal of Biomechanics
Saulo MartelliMarcus G Pandy

Abstract

The determination of femoral strain in post-menopausal women is important for studying bone fragility. Femoral strain can be calculated using a reference musculoskeletal model scaled to participant anatomies (referred to as scaled-generic) combined with finite-element models. However, anthropometric errors committed while scaling affect the calculation of femoral strains. We assessed the sensitivity of femoral strain calculations to scaled-generic anthropometric errors. We obtained CT images of the pelves and femora of 10 healthy post-menopausal women and collected gait data from each participant during six weight-bearing tasks. Scaled-generic musculoskeletal models were generated using skin-mounted marker distances. Image-based models were created by modifying the scaled-generic models using muscle and joint parameters obtained from the CT data. Scaled-generic and image-based muscle and hip joint forces were determined by optimisation. A finite-element model of each femur was generated from the CT images, and both image-based and scaled-generic principal strains were computed in 32 regions throughout the femur. The intra-participant regional RMS error increased from 380με (R(2)=0.92, p<0.001) to 4064με (R(2)=0.48, p<0.001), re...Continue Reading

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Citations

May 14, 2016·Biomechanics and Modeling in Mechanobiology·F GhezelbashA Plamondon
Sep 25, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Rami M A Al-DiriniMark Taylor
Jun 20, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mariana E KershMarcus G Pandy
Oct 4, 2018·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Emiliano P RaveraPaola A Catalfamo Formento
Nov 16, 2019·Computer Methods in Biomechanics and Biomedical Engineering·Bertram TaetzGabriele Bleser
Feb 28, 2020·Annals of Biomedical Engineering·Hamed ZiaeipoorSaulo Martelli
Apr 27, 2020·Current Osteoporosis Reports·Saulo MartelliMark Taylor

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