PMID: 9542935May 23, 1998Paper

Sensitivity of fluorochrome microscopy for detection of Mycobacterium tuberculosis versus nontuberculous mycobacteria

Journal of Clinical Microbiology
P W WrightD E Griffith

Abstract

The results for 6,532 consecutive mycobacterial respiratory specimens collected from 1,040 patients from 1993 to 1995 in a Texas hospital were studied to determine the sensitivity of fluorescence microscopy for detection of Mycobacterium tuberculosis and nontuberculous mycobacteria (NTM). Smears were positive for acid-fast bacilli (AFB) in 63% (677 of 1,082) of specimens growing M. tuberculosis and 56% (638 of 1,148) of specimens growing the four most common species of NTM. Smear positivity by species was 58% (446 of 776) for M. avium complex, 51% (154 of 300) for rapidly growing mycobacteria (98% were M. abscessus), 78% (29 of 37) for M. kansasii, and 26% (9 of 35) for M. gordonae. Definite or probable disease by clinical criteria was present in 79% of patients with M. avium complex, 93% of patients with rapidly growing mycobacteria, 100% of patients with M. kansasii, and 0% of patients with M. gordonae. Patients with M. avium complex had a low incidence of AIDS (7%), and approximately 50% of non-AIDS patients had upper-lobe cavitary disease and 50% had nodular bronchiectasis. Only 23 of 6,532 (0.35%) of AFB smears were positive with a negative culture excluding patients on therapy for established mycobacterial disease. These ...Continue Reading

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Citations

Oct 14, 1998·American Journal of Respiratory and Critical Care Medicine·R J WallaceD E Griffith
Dec 12, 2001·American Journal of Respiratory and Critical Care Medicine·N W Schluger
Jan 27, 2009·International Journal of Clinical Practice·E E McGrathUNKNOWN Infectious Diseases Society of America
Nov 10, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R J KothavadeU R Kothavade
Sep 5, 2020·Indian Journal of Medical Microbiology·Sanam Rasool WaniReena Raveendran
Mar 30, 2004·Diagnostic Cytopathology·Colleen A WrightGladwyn Leiman
May 7, 2008·The Korean journal of laboratory medicine·Ho Eun ChangEui Chong Kim
Aug 30, 2007·The Journal of Infectious Diseases·Mark D Perkins, Jane Cunningham
Dec 14, 2018·Clinical Chemistry·Hillary N WoodKyle H Rohde
Feb 6, 2007·American Journal of Respiratory and Critical Care Medicine·David E GriffithUNKNOWN Infectious Disease Society of America
Feb 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D E GriffithR J Wallace
Feb 17, 2021·Indian Journal of Medical Microbiology·Sanam Rasool WaniReena Raveendran
Feb 15, 2019·PLoS Neglected Tropical Diseases·Susan L BaldwinRhea N Coler
Oct 12, 2016·Microbiology Spectrum·Patricia J SimnerNancy L Wengenack
Oct 10, 2002·Clinics in Chest Medicine·Akos SomoskoviMax Salfinger

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