Sensitivity of gastric acid secretion in patients with chronic renal failure

Scandinavian Journal of Gastroenterology
K Ala-KailaP Sipponen

Abstract

By means of a dose-response secretion test the sensitivity of gastric acid secretion was investigated in 85 patients with chronic renal failure and in 85 age- and sex-matched controls. The renal patients were also gastroscoped, with biopsy specimens taken from the gastric body. The examinations were repeated on 18 patients undergoing regular dialysis and 8 patients after successful transplantation. The acid secretion sensitivity of the stomach among the non-dialyzed patients was decreased when compared with the controls (p less than 0.01) but tended to normalize during the intermittent dialysis treatment (p less than 0.05) and particularly after transplantation (p less than 0.01). The low secretion responses were independent of gastric body histology and were also seen in patients with normal body mucosa. The maximum theoretic acid output did not differ significantly from that of the controls. It is concluded that there is an inhibition of gastric acid secretion in chronic renal failure. This inhibition depends on the decreased sensitivity to stimulation and is diminished by treatment of renal failure by dialysis or transplantation.

References

Aug 31, 1979·World Journal of Surgery·M M LinderR Rethel
Dec 1, 1979·The Australian and New Zealand Journal of Surgery·P R MeechG J Clunie
Aug 31, 1979·World Journal of Surgery·J Hansky
Sep 1, 1985·Scandinavian Journal of Gastroenterology·H Paimela
Aug 1, 1974·Archives of Surgery·P K SpanosJ S Najarian
Jan 19, 1974·British Medical Journal·A M ShepherdK G Wormsley
Dec 1, 1971·The Journal of Endocrinology·A D CareP C Ganguli
Jun 18, 1971·Science·C W CooperD A Ontjes
Jan 1, 1968·Scandinavian Journal of Gastroenterology·M SiuralaM Kekki
Dec 1, 1984·American Journal of Surgery·K R SirinekB A Levine
Aug 1, 1982·Journal of Clinical Gastroenterology·V P DinosoS Simonian

❮ Previous
Next ❯

Citations

May 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·I RantalaK Ala-Kaila
Jul 1, 1991·Scandinavian Journal of Gastroenterology·I ParonenA L Karvonen
Aug 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K Ala-KailaA Pasternack
Nov 12, 2015·World Journal of Gastrointestinal Pharmacology and Therapeutics·Shen-Shong Chang, Hsiao-Yun Hu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.