Sensitivity of herpes simplex virus types 1 and 2 to three preparations of human interferon

The Journal of Infectious Diseases
J C OverallE R Kern

Abstract

Ten isolates of herpes simplex virus (HSV) type 1 and nine isolates of HSV type 2 were tested against virus-induced (alpha), fibroblast (beta), and mitogen-induced (gamma) preparations of human interferon (HuIFN). HSV type 2 was slightly more sensitive and HSV type 1 somewhat less sensitive to all three preparations of HuIFN than Sindbis and vesicular stomatitis virus-both considered to be quite sensitive to HuIFN. HSV type 2 was significantly more sensitive than HSV type 1 to each of the HuIFN preparations (P less than 0.01; Mann-Whitney ranksum test). Clinical isolates did not appear to differ from laboratory strains. These results indicate that both HSV types 1 and 1 are sensitive to the three different preparations of HuIFN. HuIFN may have a role in natural recovery from and may have potential as an antriviral chemotherapeutic agent in HSV infections in humans.

Citations

Mar 11, 1992·Antiviral Research·M LebwohlP Bradstreet
Apr 1, 1984·Clinics in Dermatology·M Seidlin, S E Straus
Jul 1, 1987·Antimicrobial Agents and Chemotherapy·L J EronP I Nadler
Jan 11, 2001·Drugs·D T Leung, S L Sacks
Jul 14, 2010·International Journal of Dermatology·Martha H VieraBrian Berman
Nov 1, 1988·International Journal of Dermatology·F P FlowersL A Turner
Apr 1, 1984·Journal of Clinical Microbiology·R W FultonJ M Cummins

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Australian Journal of Experimental Biology and Medical Science
L D PearsonI D Marshall
Journal of the American Academy of Dermatology
M K McCray, C Zugerman
Antimicrobial Agents and Chemotherapy
L J EronD Santomauro
© 2021 Meta ULC. All rights reserved