Sensitivity of hippocampal 5-HT1A receptors to mild stress in BDNF-deficient mice

The International Journal of Neuropsychopharmacology
Teresa F BurkeJ G Hensler

Abstract

Serotonin 1A (5-HT(1A)) receptors in brain play an important role in cognitive and integrative functions, as well as emotional states. Decreased brain-derived neurotrophic factor (BDNF) expression and/or function, particularly in hippocampus, are implicated in the pathophysiology of stress-related disorders such as major depression. BDNF(+/-) mice are more vulnerable to stress than wild-type mice, exhibiting behavioural despair after mild handling stress. We examined the effect of mild handling stress on 5-HT(1A) receptor function, as measured by 8-OH-DPAT stimulated [(35)S]GTPγS binding, in BDNF(+/-) mice and mice with a forebrain-specific reduction in BDNF (embryonic BDNF inducible knockout mice). Our data show a remarkable sensitivity of hippocampal 5-HT1A receptors to mild stress and a deficiency in BDNF. Other 5-HT(1A) receptor populations, specifically in frontal cortex and dorsal raphe, were resistant to the combined detrimental effects of mild stress and reductions in BDNF expression. Decreases in hippocampal 5-HT(1A) receptor function induced by mild stress in BDNF-deficient mice were prevented by administration of the selective serotonin reuptake inhibitor fluoxetine, which increased activation of TrkB, the high affin...Continue Reading

References

Jan 1, 1990·Annals of the New York Academy of Sciences·G K AghajanianK Rasmussen
Aug 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·E Le PoulL Lanfumey
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·M KorteT Bonhoeffer
Mar 15, 1995·Biological Psychiatry·C R McKittrickR R Sakai
Jul 1, 1994·Trends in Pharmacological Sciences·P Blier, C de Montigny
Feb 5, 1996·The Journal of Comparative Neurology·H K KiaD Vergé
May 14, 1998·Journal of Neuroscience Research·J A SiuciakA F Russo
Aug 5, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E Gould
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·E T KavalaliR W Tsien
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·W E LyonsL Tessarollo
May 24, 2000·British Journal of Pharmacology·J J HaganD R Thomas
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z SarnyaiM Toth
Apr 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julie G Hensler
May 3, 2003·Seminars in Clinical Neuropsychiatry·Amelia Russo-Neustadt
Nov 25, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shigeo MiyataJunzo Kamei
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas FrogerLaurence Lanfumey
Mar 23, 2004·European Journal of Pharmacology·Peter B HedlundPascal Bonaventure
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Lisa M MonteggiaEric J Nestler
Jan 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takanori HashimotoDavid A Lewis
Feb 8, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alfredo Briones-ArandaOfir Picazo
Apr 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bryan W LuikartLuis F Parada
Jun 1, 2005·Brain Research. Molecular Brain Research·Ashwana D FrickerIvone Gomes
Jul 23, 2005·The International Journal of Neuropsychopharmacology·Dania V RossiJulie G Hensler

❮ Previous
Next ❯

Citations

Dec 12, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiaofang LanGuangqin Li
Apr 8, 2014·Neuroscience and Biobehavioral Reviews·Judith Regina HombergMarco A Riva
Aug 2, 2015·The International Journal of Neuropsychopharmacology·Allison M DuganJason C O'Connor
Apr 16, 2015·Frontiers in Cellular Neuroscience·Annamaria CattaneoCarmine Maria Pariante
Oct 21, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Megumi AdachiLisa M Monteggia
Mar 25, 2017·The International Journal of Neuropsychopharmacology·Feng-Guo LiuChao Huang
Dec 20, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefanie C AltieriAnne M Andrews
Jan 22, 2019·Expert Opinion on Therapeutic Targets·Nina K Popova, Vladimir S Naumenko
Jul 25, 2021·International Journal of Molecular Sciences·Julia LeschikAntonietta Gentile

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.