PMID: 6165278Jan 1, 1980Paper

Sensitivity of human ovarian carcinoma cells to interferon and other antitumor agents as assessed by an in vitro semi-solid agar technique

Annals of the New York Academy of Sciences
L B EpsteinC C Reese

Abstract

To determine the sensitivity in vitro of human ovarian carcinoma cells to the antiproliferative effects of human leukocyte interferon, 18 samples of ascitic fluid from 15 affected patients were cultured in semi-solid agar by the technique of Hamburger and Salmon. Cultures were examined at weekly intervals after initiation and the number and size of each tumor colony recorded. Growth as defined by increase in total tumor colony number with time was obtained in 45% of the samples, or 53% of the patients, or 67% of the ascitic fluid samples with tumor cells demonstrated by Pap smear. No growth occurred in samples from recently treated patients or in samples devoid of tumor cells as assessed by Pap smear. Response to interferon directly incorporated into the agar culture system or preincubated with cells prior to their inclusion in culture was defined as reduction in total colony number by greater than or equal to 50% and partial response by greater than or equal to 25% reduction. The response rate for samples, The nontreated controls of which showed evidence of growth, was 71%, and that of samples that contained tumor colonies with no increase in growth during the culture period was 75%. Sensitivity to interferon was not related t...Continue Reading

References

Jun 15, 1978·The New England Journal of Medicine·S E SalmonT E Moon
Oct 15, 1977·International Journal of Cancer. Journal International Du Cancer·F R Balkwill, R T Oliver
Oct 1, 1977·The Journal of Clinical Investigation·A Hamburger, S E Salmon
Dec 28, 1978·The New England Journal of Medicine·T C MeriganS A Rosenberg
Feb 1, 1979·Journal of Cellular Physiology·A W HamburgerS E Salmon
Jul 29, 1977·Science·A W Hamburger, S E Salmon
Jan 1, 1978·Advances in Experimental Medicine and Biology·S Einhorn, H Strander

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Citations

Jan 1, 1984·Journal of Interferon Research·M N GouldE C Borden
Aug 1, 1987·Journal of Interferon Research·Y KimotoT Taguchi
Jan 1, 1982·Cancer Chemotherapy and Pharmacology·D D Von HoffC A Coltman
Oct 1, 1984·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·K BucksheeT N Chapekar
Sep 1, 1986·Gynecologic Oncology·S SekiyaH Takamizawa
Jun 7, 2013·The Cochrane Database of Systematic Reviews·Aramide O LawalLiesl Grobler
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·W J Richtsmeier
Mar 1, 1985·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·D W Meinke
May 29, 2014·The Journal of Biological Chemistry·Peter Lengyel
Jun 15, 1985·International Journal of Cancer. Journal International Du Cancer·C E WelanderR J Spiegel
Jun 24, 2011·Cancer Research·Sana Intidhar Labidi-GalyNathalie Bendriss-Vermare

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