Sensitivity of Initial Thoracentesis for Malignant Pleural Effusion Stratified by Tumor Type in Patients with Strong Evidence of Metastatic Disease

Respiration; International Review of Thoracic Diseases
Horiana B GrosuDavid E Ost

Abstract

Thoracentesis with cytological examination of pleural fluid is the initial test of choice for evaluation of pleural effusions in patients with suspected malignant pleural effusion (MPE). There is limited data on the sensitivity of thoracentesis stratified by tumor type. A better understanding of stratified sensitivities is of clinical interest, and may guide early and appropriate referral for pleural biopsy. The primary objective was sensitivity of thoracentesis with pleural fluid cytology stratified by tumor type. This is a retrospective cohort study of consecutive patients with a solid tumor malignancy with proven or strong suspicion for metastatic disease with new pleural effusions that underwent an initial thoracentesis. Only patients with metastatic disease were included. Of the 725 patients examined, 63% had pleural fluid cytology positive for malignancy. Sensitivity of thoracentesis varied from a low of 0.38 (95% CI 0.13-0.68) in head and neck malignancy, 0.38 (95% CI 0.15-0.65) in sarcoma, and 0.53 (95% CI 0.34-0.72) in renal cancer to a high of 93 (95% CI 88-97) in breast cancer, and 100 (95% CI 0.82-100) in pancreatic cancer. Factors associated with an increased risk of MPE included larger amount of fluid drained (p =...Continue Reading

Citations

Oct 24, 2019·Expert Review of Respiratory Medicine·Lucía FerreiroLuis Valdés
Dec 5, 2020·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Lucía FerreiroLuis Valdés
Apr 9, 2019·The Medical Clinics of North America·Matthew Aboudara, Fabien Maldonado
Aug 12, 2019·The American Journal of Medicine·Marshall BaileyHoriana B Grosu
Jun 3, 2021·Methods and Protocols·Dionysios AntonopoulosNikolaos A A Balatsos
Jun 29, 2021·Pleura and Peritoneum·José M PorcelAntonieta Salud

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Respirology : Official Journal of the Asian Pacific Society of Respirology
Horiana B GrosuDavid E Ost
The Journal of the Egyptian Public Health Association
M N el-BolkainyM A Mansour
The European Respiratory Journal
David T ArnoldNick A Maskell
© 2022 Meta ULC. All rights reserved