Sensitivity of multidrug-resistant tumor cell lines to immunologic effector cells

Cellular Immunology
I G Schmidt-WolfR S Negrin

Abstract

The ability of malignant cells to survive exposure to cytotoxic agents is a major obstacle to cure in patients with cancer. Multidrug resistance and the expression of P-glycoprotein are emerging as a cause of chemotherapy failure. Immunologic effector cells such as lymphokine-activated killer (LAK) cells or cytokine-induced killer (CIK) cells are capable of killing a broad range of tumor cell lines or freshly isolated tumor cells. As demonstrated here, LAK, and CIK cells possess a high level of cytotoxic activity against tumor cell lines both resistant and sensitive to chemotherapeutic agents such as doxorubicin or vinblastine. CIK cells possessed a higher level of cytotoxic activity than LAK cells as determined by 51Cr release and a tumor colony assay. Monoclonal antibodies against P-glycoprotein did not block the lysis of tumor cells resistant to chemotherapy by CIK cells. In contrast, antibodies to LFA-1 and ICAM-1 blocked CIK cell-mediated tumor cell lysis. These data demonstrate that immunological approaches to cancer therapy may be useful in overcoming disease caused by drug resistance.

Citations

Feb 17, 2006·Cancer Biotherapy & Radiopharmaceuticals·Xiubao RenXishan Hao
Jun 1, 1997·Immunological Reviews·K A MargolinS J Forman
Aug 31, 2010·Journal of Experimental & Clinical Cancer Research : CR·Qun ZhaoLiqiao Fan
Dec 25, 2010·World Journal of Gastroenterology : WJG·Jing-Ting JiangXue-Guang Zhang
Apr 18, 2014·Journal of Immunology Research·Clara E JäkelIngo G H Schmidt-Wolf
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·T J SweeneyC H Contag
Sep 10, 2014·International Journal of Molecular Sciences·Frederic Carsten SchmeelIngo G H Schmidt-Wolf
Apr 17, 2012·Expert Opinion on Biological Therapy·Giulia MesianoDario Sangiolo
Aug 13, 2014·Journal of Translational Medicine·Xiao-Dong LiJing-Ting Jiang
May 2, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yong-Qian Shu, Yanhong Gu
Apr 2, 2011·Clinical & Developmental Immunology·Yao WangWeidong Han
Nov 30, 2012·Clinical & Developmental Immunology·Clara E JäkelIngo G H Schmidt-Wolf
Jun 15, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ginna G LaportRobert S Negrin
Apr 7, 2010·Journal of Biomedicine & Biotechnology·Yeh Ching Linn, Kam M Hui
Dec 31, 1997·American Journal of Reproductive Immunology : AJRI·C M YasharC Gerçel-Taylor
Jan 26, 2018·International Journal of Molecular Sciences·Martino Introna, Fabio Correnti
Jun 11, 2005·World Journal of Gastroenterology : WJG·You-Shun ZhangZong-Qing Dai
Mar 12, 2003·International Journal of Hematology·Suradej HongengSaengsuree Jootar
Apr 30, 2015·Immune Network·Ji Sung KimSang-Bae Han
Dec 18, 2018·Journal of Cellular Biochemistry·Solmaz ShirjangMehdi Yousefi
Feb 4, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Xiao-Dong LiChang-Ping Wu
Aug 9, 2001·Blood·G Laurent, J P Jaffrézou
Sep 23, 2000·Journal of Immunotherapy·K E SchilbachR Handgretinger

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