PMID: 2505285Jan 1, 1989Paper

Sensitivity of pentylenetetrazol discrimination increased by a stimulus fading technique

Psychopharmacology
C M HarrisH Lal

Abstract

The interoceptive stimulus produced by pentylenetetrazol (PTZ) is pharmacologically similar to anxiety and is used in a behavioral assay for anxiety-related stimuli (the PTZ model of anxiety). The stimulus fading technique was tested as a method to increase the sensitivity of this assay. Rats were trained with food-reward to press one lever after injection of PTZ and an alternate lever after saline. Rats initially learned the discrimination at a PTZ dose of 20 mg/kg. They were then trained with sequentially lower doses until they reliably discriminated a PTZ dose of 10 mg/kg. Substitution tests with other doses and drugs showed that, after the fading procedure, dose-response curves were shifted to lower doses for PTZ, Ro 5-3663, and nicotine Similarly, the dose of diazepam required to block the low dose of PTZ was lower than that required to block the higher dose of PTZ. These results indicated that the sensitivity of the discrimination was enhanced in rats trained to discriminate a lower dose of PTZ. Doses of nikethamide, cocaine, and yohimbine that did not substitute for the higher dose of PTZ also did not substitute for the lower dose. These data suggest that rats can be trained to discriminate a low dose of PTZ by the stimu...Continue Reading

References

Sep 17, 1975·Psychopharmacologia·I GreenbergJ B Appel
Jan 1, 1987·Psychopharmacology·M W Emmett-Oglesby, A Herz
Jan 1, 1984·Psychopharmacology·L H JensenR Schmiechen
Dec 1, 1983·Neuropharmacology·H Lal, M W Emmett-Oglesby
Jan 1, 1982·Psychopharmacology·F J White, J B Appel
Sep 1, 1982·Pharmacology, Biochemistry, and Behavior·M W Emmett-OglesbyD E Arnoult

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Citations

Jan 1, 1990·Psychopharmacology·M W Emmett-OglesbyH Lal
Jan 1, 1995·Pharmacology, Biochemistry, and Behavior·A TomieL L Peoples
Nov 1, 1992·Behavioral and Neural Biology·D M Skinner, G M Martin
Sep 6, 2003·Pharmacology, Biochemistry, and Behavior·Michael B GatchMichael J Forster
Sep 3, 2002·Neuroscience and Biobehavioral Reviews·Marianna E JungMichael B Gatch
May 10, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·I Tayfun Uzbay, Harbans Lal

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