Sensitivity of selected immunological, hematological, and reproductive parameters in the cotton rat (Sigmodon hispidus) to subchronic lead exposure

Journal of Wildlife Diseases
S T McMurryC W Qualls

Abstract

The effect of lead exposure on cellular immunity, hematology, and reproductive and body condition in mature cotton rats (Sigmodon hispidus) was examined. Two groups of 36 cotton rats each were exposed to 0, 100, or 1,000 ppm lead in drinking water for either 7 or 13 weeks, between 31 August and 2 December 1990. Specific and non-specific cell-mediated immunity was assessed by measuring splenocyte proliferative responses to polyclonal mitogens (Concanavalin A and Pokeweed mitogen), in vivo 24-hr delayed-type hypersensitivity, metabolic activity of peritoneal macrophages, spleen mass and cellularity, and immune organ development. General physiological condition was assessed from hematological, morphological, and reproductive measures. Immune function was sensitive to lead exposure based on depressed proliferative responses of cultured splenocytes, smaller popliteal lymph nodes, and larger spleens among cotton rats receiving 1,000 ppm lead. Spleen mass was reduced in cotton rats receiving 100 ppm lead. Total leukocytes, lymphocytes, neutrophils, eosinophils, total splenocyte yield, packed cell volume, hemoglobin, and mean corpuscular hemoglobin were sensitive to lead exposure. Effects of lead exposure on general condition and repro...Continue Reading

Citations

Feb 1, 2006·Archives of Environmental Contamination and Toxicology·María E ChiesaAlfredo Salibián
Nov 27, 1999·International Journal of Immunopharmacology·L InstitórisL Nagymajtenyi
Aug 25, 2004·Environmental Pollution·Katrien TersagoRon Verhagen
Jan 31, 2015·Ecotoxicology·Hebe FerreyraMarcela Uhart
Aug 17, 2016·International Journal of Molecular Sciences·Faiza RaoFei Sun
Dec 7, 2013·Toxicology and Industrial Health·Shafaat Yar KhanHafiz Muhammad Tahir
Jan 30, 2003·Journal of Toxicology and Environmental Health. Part a·James WilsonNicholas Basta

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