Sensitivity of Thoracic Digital Tomosynthesis (DTS) for the Identification of Lung Nodules

Journal of Digital Imaging
Steve G LangerBrian J Bartholmai

Abstract

Thoracic computed tomography (CT) is considered the gold standard for detection lung pathology, yet its efficacy as a screening tool in regards to cost and radiation dose continues to evolve. Chest radiography (CXR) remains a useful and ubiquitous tool for detection and characterization of pulmonary pathology, but reduced sensitivity and specificity compared to CT. This prospective, blinded study compares the sensitivity of digital tomosynthesis (DTS), to that of CT and CXR for the identification and characterization of lung nodules. Ninety-five outpatients received a posteroanterior (PA) and lateral CXR, DTS, and chest CT at one care episode. The CXR and DTS studies were independently interpreted by three thoracic radiologists. The CT studies were used as the gold standard and read by a fourth thoracic radiologist. Nodules were characterized by presence, location, size, and composition. The agreement between observers and the effective radiation dose for each modality was objectively calculated. One hundred forty-five nodules of greatest diameter larger than 4 mm and 215 nodules less than 4 mm were identified by CT. DTS identified significantly more >4 mm nodules than CXR (DTS 32 % vs. CXR 17 %). CXR and DTS showed no signific...Continue Reading

References

Oct 29, 2003·Physics in Medicine and Biology·James T Dobbins, Devon J Godfrey
Sep 13, 2006·Journal of Biomedical Optics·Brian W Pogue, Michael S Patterson
Oct 27, 2006·The New England Journal of Medicine·UNKNOWN International Early Lung Cancer Action Program InvestigatorsOlli S Miettinen
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jul 1, 2011·The New England Journal of Medicine·UNKNOWN National Lung Screening Trial Research TeamJoRean D Sicks
Feb 7, 2015·Journal of Thoracic Imaging·Brian J BartholmaiThomas E Hartman

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Citations

Jun 27, 2018·BMC Gastroenterology·Maria Magdalena BuijsGunnar Baatrup
Apr 22, 2017·La Radiologia medica·Maurizio GrossoUNKNOWN SOS Study Group

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