Sensitivity of unanesthetized chinchilla auditory system to noise burst onset, and the effects of carboplatin

Hearing Research
D P PhillipsR Burkard

Abstract

The gross near-field responses of the auditory nerve and inferior colliculus to noise burst stimuli were recorded through intracranially implanted electrodes in six unanesthetized chinchillas. Responses were studied as a function of stimulus plateau amplitude and rise time, both before and after a systemic dose of 75 mg/kg of carboplatin. Both recording sites showed sensitivity to stimulus level and rise time. Increases in stimulus level and decreases in stimulus rise time each produced increases in the response magnitude, and decreases in response latency. When the stimuli were re-specified as rate of pressure change at sound onset (Pa/s), the amplitude and latency of responses at each site were found to be a direct function of rate of sound pressure change. These data provide the first confirmation in unanesthetized animals of previous single unit observations in barbiturate-anesthetized cats. Carboplatin treatment resulted in a 20-80% loss of inner hair cells, a modest threshold elevation, and a 50-75% reduction in peak response amplitudes. The general patterns of sensitivity to stimulus level and rise time were not markedly affected by carboplatin, nor was the fashion in which response parameters (amplitude and latency) wer...Continue Reading

References

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Citations

Jul 16, 2002·Hearing Research·D P PhillipsS E Boehnke
Apr 16, 2002·Ear and Hearing·M Sasha JohnTerence W Picton
Oct 10, 2003·Ear and Hearing·M S JohnT W Picton
Jul 24, 2010·The Journal of the Acoustical Society of America·C D Cowper-SmithD P Phillips
Aug 21, 2002·The Journal of the Acoustical Society of America·Sally Arnold, Robert Burkard
Aug 7, 2004·The Journal of the Acoustical Society of America·Henry SimonJoseph P Walton
Jun 4, 2019·The Journal of the Acoustical Society of America·Ryan JonesRobert F Burkard
Jun 3, 2018·The Journal of the Acoustical Society of America·James J FinneranRobert F Burkard
Dec 3, 2020·The Journal of the Acoustical Society of America·James J FinneranRobert F Burkard

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