Sensitivity of White and Opaque Candida albicans Cells to Antifungal Drugs

Antimicrobial Agents and Chemotherapy
Veronica B CraikMatthew B Lohse

Abstract

White and opaque cells of Candida albicans have the same genome but differ in gene expression patterns, metabolic profiles, and host niche preferences. We tested whether these differences, which include the differential expression of drug transporters, resulted in different sensitivities to 27 antifungal agents. The analysis was performed in two different strain backgrounds; although there was strain-to-strain variation, only terbinafine hydrochloride and caspofungin showed consistent, 2-fold differences between white and opaque cells across both strains.

References

Dec 1, 1987·Journal of Bacteriology·J M Anderson, D R Soll
Feb 1, 1968·Die Naturwissenschaften·G Maestrone, R Semar
Oct 1, 1968·The Journal of Antibiotics·A AszalosB Berk
Feb 1, 1993·Trends in Genetics : TIG·D R SollT Srikantha
Dec 11, 1997·Journal of Bacteriology·I BalanM Raymond
Jun 21, 2002·Methods in Enzymology·Fred Sherman
Oct 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Chung-Yu LanNina Agabian
Mar 24, 2004·Nature Reviews. Microbiology·Alexander Johnson
Feb 10, 2009·Current Biology : CB·Guanghua HuangDavid R Soll
Sep 12, 2009·FEMS Yeast Research·David R Soll
Oct 27, 2009·Current Opinion in Microbiology·Matthew B Lohse, Alexander D Johnson
Apr 15, 2010·Medical Microbiology and Immunology·Joachim Morschhäuser
Aug 26, 2010·Molecular Microbiology·Matthew B Lohse, Alexander D Johnson
Sep 28, 2010·Acta Biochimica Et Biophysica Sinica·Xinyi NieJiangye Chen
Sep 6, 2015·Eukaryotic Cell·Yuan SunGuanghua Huang

❮ Previous
Next ❯

Citations

Jan 18, 2018·Pathogens·Christina Braunsdorf, Salomé LeibundGut-Landmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.