Sensitivity to 6-n-propylthiouracil is associated with gustin (carbonic anhydrase VI) gene polymorphism, salivary zinc, and body mass index in humans

The American Journal of Clinical Nutrition
Alessandra PadigliaIole Tomassini Barbarossa

Abstract

The individual ability to taste 6-n-propylthiouracil (PROP) may be correlated with body mass index (BMI) and differences in the salivary proteins involved in taste function, such as the zinc-dependent enzyme gustin, which is a trophic factor of taste buds. We investigated the possible association of PROP taste responsiveness with gustin gene polymorphism rs2274333 (A/G), salivary ionic zinc concentrations, and BMI. We measured cognitive eating behaviors and BMI in 75 volunteers (28 men and 47 women; mean plusmn SEM age: 25 plusmn 3 y). The intensity of taste perception evoked by PROP and sodium chloride solutions was estimated to evaluate PROP taster status. Salivary ionic zinc concentrations were measured, and molecular analyses of the gustin gene polymorphism were performed in individuals classified by PROP status by using polymerase chain reaction techniques. We classified subjects as PROP supertasters (n = 27), medium tasters (n = 28), or nontasters (n = 20). Salivary ionic zinc concentrations and BMI were greater in nontasters than in supertasters (P = 0.003 and P = 0.042, respectively). Molecular analyses of gustin DNA showed that allele A and genotype AA were significantly more frequent in supertasters, whereas allele G ...Continue Reading

Associated Clinical Trials

Apr 2, 2010·Iole Tomassini Barbarossa, Iole Tomassini Barbarossa

References

Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R I HenkinH Edelhoch
Jul 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S ParkkilaH Rajaniemi
Nov 1, 1990·Brain Research Bulletin·P M Di Lorenzo, S Monroe
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J S LawR I Henkin
Jan 1, 1986·Journal of Gerontology·L M BartoshukP Bars
Jan 1, 1985·Journal of Psychosomatic Research·A J Stunkard, S Messick
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A R Shatzman, R I Henkin
May 29, 1980·Biochimica Et Biophysica Acta·A R Shatzman, R I Henkin
Jun 1, 1995·Archives of Oral Biology·R T FernleyE J Cooper
Dec 1, 1994·Physiology & Behavior·L M BartoshukI J Miller
Jun 1, 1997·Physiology & Behavior·B J Tepper, R J Nurse
Oct 24, 1998·Biochemical and Biophysical Research Communications·B J ThatcherR I Henkin
Feb 4, 1999·Annals of the New York Academy of Sciences·L M BartoshukK Fast
Feb 4, 1999·Annals of the New York Academy of Sciences·B J Tepper, R J Nurse
Apr 15, 2000·Physiology & Behavior·L C KaminskiA Drewnowski
Jun 23, 2000·Journal of the American Dietetic Association·V B Duffy, L M Bartoshuk
Jun 27, 2000·Bioinformatics·L J McGuffinD T Jones
Mar 29, 2001·Physiology & Behavior·C Yackinous, J X Guinard
Apr 11, 2001·Annals of Human Biology·S W Guo, D R Reed
Apr 17, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J LeinonenH Rajaniemi
Aug 10, 2001·Physiology & Behavior·B J TepperJ Cao
Jun 26, 2003·Nucleic Acids Research·Rune LindingToby J Gibson
May 1, 1958·Annals of Human Genetics·H KALMUS
Nov 18, 2004·Alcoholism, Clinical and Experimental Research·Valerie B DuffyLinda M Bartoshuk
Jun 25, 2005·Obesity Research·Gretchen L GoldsteinBeverly J Tepper
Jul 30, 2005·Current Biology : CB·Nicole SoranzoDavid B Goldstein
Aug 30, 2005·Physiology & Behavior·Kathleen S CurtisRobert J Contreras
Jan 1, 1932·Proceedings of the National Academy of Sciences of the United States of America·A L Fox
Apr 14, 2007·Current Protein & Peptide Science·Zsuzsanna DosztányiIstván Simon
May 5, 2007·Physiology & Behavior·Martin R YeomansJohn Prescott
Jul 27, 2007·The British Journal of Nutrition·Barbara J Stewart-KnoxJ J Strain
Jul 31, 2007·Journal of the American Dietetic Association·Adam DrewnowskiJennie E Cockroft
Jan 1, 2008·Molecular Ecology Resources·François Rousset

❮ Previous
Next ❯

Citations

Jul 24, 2013·Food Quality and Preference·John E HayesAlissa L Allen
Sep 15, 2012·Chemical Senses·Antti KnaapilaDanielle R Reed
Dec 18, 2013·Pharmacogenomics·Mariëlle J NagtegaalHenk-Jan Guchelaar
Nov 20, 2013·European Journal of Pediatrics·M MorzelS Nicklaus
Aug 1, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S H BouthoornH Raat
Mar 18, 2015·International Journal of Molecular Sciences·Tibor Károly FábiánGábor Fábián
Aug 20, 2014·Journal of Biomedical Science·Maarit PatrikainenSeppo Parkkila
May 23, 2016·Transgenic Research·Maarit S PatrikainenSeppo Parkkila
Nov 24, 2017·Nutrients·Beverly J TepperIole Tomassini Barbarossa
Apr 18, 2018·The Proceedings of the Nutrition Society·Carolina Muñoz-GonzálezFrancis Canon
Sep 1, 2017·Journal of Nutrigenetics and Nutrigenomics·Natasha Chong ColeUNKNOWN STRONG Kids Team
Dec 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·Rossella NegriLuigi Greco
Jan 11, 2020·Annual Review of Food Science and Technology·Alissa A Nolden, Emma L Feeney
Nov 22, 2016·Journal of Neuroscience Research·Louis J Martin, Suzanne I Sollars
Aug 10, 2020·Medical Molecular Morphology·Gül Yıldız TelatarBaris Can Telatar

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