Sensitivity to carbon dioxide in subjects with a single lifetime panic attack: possible clinical "bedside" predictive test for panic disorder after a first attack

Depression and Anxiety
Elina BerzakJonathan Benjamin

Abstract

There is currently no way of knowing whether a patient who has recently had a single panic attack has incipient panic disorder. Sensitivity to carbon dioxide (CO2) is lower in healthy volunteers than in panic disorder patients. If this is also true of people who experience a single lifetime panic attack, it could be used as a prognostic test. Subjects with a single lifetime panic attack and subjects with panic disorder received an inhalation of 35% CO2. Subjects completed the panic symptoms scale (PSS), and also stated whether they considered that they had experienced an attack. None of 14 subjects with a single lifetime panic attack, compared to 7 of 17 subjects with panic disorder (P=.009), had an attack. The PSS also distinguished between the groups. The 35% CO2 challenge warrants further investigation as a predictive test after a first panic attack.

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Citations

Oct 12, 2010·European Archives of Psychiatry and Clinical Neuroscience·J DiemerP Zwanzger
Feb 11, 2012·Clinical Psychology Review·Kristin VickersAndrea Woznica
Nov 3, 2016·Iranian Journal of Psychiatry and Behavioral Sciences·Afshan NajafiAzadeh Mazaheri Meybodi
Jan 13, 2006·Journal of Psychiatric Research·Bella TalesnikJonathan Benjamin
Aug 19, 2014·Neuroscience and Biobehavioral Reviews·Philip L JohnsonAnantha Shekhar
Dec 1, 2020·Journal of Psychiatric Research·Umit Tural, Dan V Iosifescu

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