Sensitivity to negative and positive feedback as a stable and enduring behavioural trait in rats

Psychopharmacology
Karolina Noworyta-SokolowskaRafal Rygula

Abstract

According to psychological theories, cognitive distortions play a pivotal role in the aetiology and recurrence of mood disorders. Although clinical evidence for the coexistence of depression and altered sensitivity to performance feedback is relatively coherent, we still do not know whether increased or decreased sensitivity to positive or negative feedback is associated with 'pro-depressive' profile in healthy subjects. Our research has been designed to answer this question, and here, we present the first steps in that direction. Using a rat version of the probabilistic reversal-learning (PRL) paradigm, we evaluated how sensitivity to negative and positive feedback influences other cognitive processes associated with mood disorders, such as motivation in the progressive ratio schedule of reinforcement (PRSR) paradigm, hedonic status in the sucrose preference (SP) test, locomotor and exploratory activity in the open field (OF) test, and anxiety in the light/dark box (LDB) test. The results of our study demonstrated for the first time that in rodents, sensitivity to negative and positive feedback could be considered a stable and enduring behavioural trait. Importantly, we also showed that these traits are independent of each oth...Continue Reading

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Citations

Mar 29, 2020·Brain and Neuroscience Advances·Matthew P WilkinsonEmma S J Robinson
Dec 19, 2020·Neurotoxicity Research·Adam WojtasKrystyna Gołembiowska
Jan 9, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Karolina Noworyta, Rafal Rygula
May 26, 2021·Psychopharmacology·Monika HerianKrystyna Gołembiowska

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