Sensitivity to ozone, diesel exhaust particles, and standardized ambient particulate matter in rats with a listeria monocytogenes-induced respiratory infection

Inhalation Toxicology
P A SteerenbergF R Cassee

Abstract

Ambient particulate matter may increase respiratory allergic skewing of the T-cell-mediated immune response toward a T-helper-2 (Th2) response, with the consequence that the Th1 response develops less well. Successful clearing of a respiratory bacterial infection depends on an adequate Th1 immune response; therefore, the subject would not control the infection as well if exposed to particulate matter. To substantiate this hypothesis, we examined the effect of exposure to diesel exhaust particles (DEP) and urban particulate matter (EHC-93, Ottawa dust) on rats with a Listeria monocytogenes respiratory infection. Since this hypothesis has been confirmed for ozone, we used it as a positive control. Wistar rats were exposed to ozone (2 mg/m3 for 24 h/day for 7 days) and to DEP or to EHC-93 (50 microg/rat intranasally daily for 7 consecutive days). Twenty-four hours after the last exposure, the rats were infected intratracheally with 1 x 10(6) L. monocytogenes bacteria. The number of L. monocytogenes was determined after 3, 4 and 5 days. Statistically significant increases of the number of L. monocytogenes in rats exposed to ozone were observed in the lungs and spleen at all three times. However, we found no significant differences ...Continue Reading

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Citations

Mar 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ilona JaspersMichael C Madden
Dec 24, 2011·Journal of Applied Physiology·Walter A ZinDébora S Faffe
Oct 4, 2011·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Tadeusz HalatekFleming R Cassee
Jun 26, 2009·Inhalation Toxicology·Mari SamuelsenMartinus Løvik
Mar 13, 2009·Critical Reviews in Toxicology·Thomas W HesterbergPeter A Valberg
Jul 8, 2021·Environmental Science & Technology·Eun Kyung LeeShao Lin
Nov 26, 2010·Particle and Fibre Toxicology·Kymberly M GowdyM Ian Gilmour

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