Sensitivity to the photoperiod and potential migratory features of neuroblasts in the adult sheep hypothalamus

Brain Structure & Function
Martine BataillerMartine Migaud

Abstract

Adult neurogenesis, a process that consists in the generation of new neurons from adult neural stem cells, represents a remarkable illustration of the brain structural plasticity abilities. The hypothalamus, a brain region that plays a key role in the neuroendocrine regulations including reproduction, metabolism or food intake, houses neural stem cells located within a hypothalamic neurogenic niche. In adult sheep, a seasonal mammalian species, previous recent studies have revealed photoperiod-dependent changes in the hypothalamic cell proliferation rate. In addition, doublecortin (DCX), a microtubule-associated protein expressed in immature migrating neurons, is highly present in the vicinity of the hypothalamic neurogenic niche. With the aim to further explore the mechanism underlying adult sheep hypothalamic neurogenesis, we first show that new neuron production is also seasonally regulated since the density of DCX-positive cells changes according to the photoperiodic conditions at various time points of the year. We then demonstrate that cyclin-dependant kinase-5 (Cdk5) and p35, two proteins involved in DCX phosphorylation and known to be critically involved in migration processes, are co-expressed with DCX in young hypotha...Continue Reading

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Citations

Feb 18, 2016·Neural Plasticity·Jan BakosDaniela Ostatnikova
May 15, 2016·Theriogenology·Martine MigaudMartine Batailler
Aug 10, 2016·The Journal of Comparative Neurology·Arsène EllaMatthieu Keller
Jan 20, 2018·Endocrine Reviews·Vincent PrevotJerome Clasadonte
Oct 5, 2017·Cellular and Molecular Life Sciences : CMLS·Didier LometHugues Dardente
Nov 8, 2017·Frontiers in Neuroscience·Frederic LévyMartine Migaud
Jul 25, 2017·Brain Structure & Function·Lucile ButruilleMartine Migaud
Sep 26, 2017·Frontiers in Neuroscience·Mariela Faykoo-MartinezMelissa M Holmes
May 7, 2019·Journal of Neuroendocrinology·Hugues DardenteCristina Sáenz de Miera
Feb 13, 2021·Animal : an International Journal of Animal Bioscience·A ZsolnaiI Anton

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