Sensitization of alveolar macrophages to lipopolysaccharide-induced prostaglandin synthesis by exogenous prostaglandins

Biochemical and Biophysical Research Communications
K TanamotoE T Rietschel

Abstract

Rabbit alveolar macrophages were found to produce extraordinary amounts of prostaglandin E2 and F2 alpha with the stimulation of lipopolysaccharide or lipid A. Exogenous prostaglandin E2 greatly enhanced the lipopolysaccharide action on rabbit alveolar macrophages for the induction of prostaglandin F2 alpha release (3-5 fold), while prostaglandin E2 alone did not cause any effect. The enhancement expressed was especially strong when prostaglandin E2 was administered to the cells simultaneously with lipopolysaccharide. The effect of prostaglandin E2 was observed neither with a nonstimulating dose of lipopolysaccharide nor with a stimulating dose of zymosan. This phenomenon was even more pronounced when prostaglandin I2 was used instead of prostaglandin E2, while no sensitization was demonstrated by prostaglandin F2 alpha. These observations suggest that prostaglandins can modulate the activation of the cyclooxygenase pathway of arachidonate metabolism in the activated macrophages by lipopolysaccharide.

References

Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·L M WahlS E Mergenhagen
Mar 15, 1979·Experimental Cell Research·R L Oropeza-RendonH Fischer
Mar 1, 1978·The Journal of Experimental Medicine·J I Kurland, R Bockman
Dec 1, 1973·FEBS Letters·A JobkeB M Peskar
Jun 1, 1969·European Journal of Biochemistry·C GalanosO Westphal

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