Sensitization of aortic and cardiac baroreceptors by arginine vasopressin in mammals

The Journal of Physiology
F M AbboudB N Gupta

Abstract

Vasopressin facilitates the baroreflex control of the circulation. The peptide may act at several sites to augment the baroreflex. In this study we examined the effect of vasopressin on aortic baroreceptors in anaesthetized rabbits and on left ventricular mechanoreceptors in anaesthetized cats. Vasopressin (16 mu./kg. min) did not change resting nerve discharge in single fibres from aortic baroreceptors. Vasopressin (16 mu./kg. min) significantly enhanced the response of single aortic nerve fibre discharge to elevation in arterial pressure. The slope relating nerve activity to mean arterial pressure increased from 0.24 +/- 0.05 (mean +/- S.E. of mean) to 0.50 +/- 0.16 impulses/cardiac cycle. mmHg (P less than 0.05) in ten aortic medullated fibres and from 0.06 +/- 0.03 to 0.18 +/- 0.04 impulses/cardiac cycle. mmHg (P less than 0.05) in three non-medullated fibres. Vasopressin (16 mu./kg. min) did not change resting nerve discharge in single fibres from left ventricular mechanoreceptors. Vasopressin (16 mu./kg. min) significantly enhanced the response of single nerve fibre discharge from left ventricular mechanoreceptors in response to elevation of left ventricular end-diastolic pressure. The slope relating nerve activity to lef...Continue Reading

Citations

Nov 1, 1992·Clinical and Experimental Pharmacology & Physiology·N H SecherS Matzen
Mar 1, 1990·Circulation Research·M Y Yang, M C Andresen
Feb 9, 1989·The New England Journal of Medicine·F M Abboud
Aug 1, 1988·Clinical and Experimental Pharmacology & Physiology·J LudbrookR L Woods
Jul 22, 1993·Annals of the New York Academy of Sciences·B J PardiniP G Schmid
Jul 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R MoreauC Sicot
Apr 15, 1993·The New England Journal of Medicine·F M Abboud
Aug 1, 1990·Circulation Research·E M Hasser, V S Bishop
Jan 1, 1989·Clinical and Experimental Pharmacology & Physiology. Supplement·M C Andresen, M Yang
Jan 1, 1997·Clinical and Experimental Pharmacology & Physiology·E M HasserM Hay
Feb 4, 2012·The Journal of Physiological Sciences : JPS·Yasuhiro NishidaKohsuke Hagisawa
Jul 1, 1995·Journal of Cardiovascular Electrophysiology·R Sutton, M E Petersen
Apr 1, 1989·The American Journal of Physiology·V L Brooks, L J Blakemore
Jan 1, 1996·Progress in Neurobiology·A J Lawrence, B Jarrott

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