Sensitization of Burkholderia cepacia to antibiotics by cationic drugs

The Journal of Antimicrobial Chemotherapy
J M Rajyaguru, M J Muszynski

Abstract

Chlorpromazine and prochlorperazine have previously been shown to enhance the susceptibility of Burkholderia cepacia to aminoglycosides. To screen other non-antibiotic drugs containing similar amine (-N-CH3) groups, we examined a range of such agents that are in current clinical use for the treatment of non-infectious diseases, in combination with antibiotics that are ineffective against B. cepacia. At a concentration of 0.2 mM, theobromine, theophylline, trifluoperazine, fluophenazine and coumarin-152 significantly reduced (by four-fold) the MICs of gentamicin and ceftazidime. Theobromine and theophylline also reduced the MICs of amikacin and azithromycin.

Citations

Apr 25, 2000·International Journal of Antimicrobial Agents·G GunicsJ Molnár
Oct 19, 2011·Antimicrobial Agents and Chemotherapy·Rebecca J MalottDavid P Speert
May 4, 2007·International Journal of Antimicrobial Agents·Janne Lehtinen, Esa-Matti Lilius
Aug 14, 2009·FEMS Microbiology Letters·Anthony M GeorgePeter G Middleton
Jun 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Antonia Eliene DuarteMarilise Escobar Burger
May 8, 2018·Journal of Medical Case Reports·Emir YonasNuvi Nusarintowati
Jun 3, 2017·The Journal of Antimicrobial Chemotherapy·A E J YsselH P Steenackers

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