Sensitization of Gram-negative bacteria to rifampin and OAK combinations

Scientific Reports
Joanna JammalAmram Mor

Abstract

While individually inefficient against Gram-negative bacteria, in-vitro combinations of rifampin and OAK were mutually synergistic since sub-minimal inhibitory concentrations of one compound have potentiated the other by 2-4 orders of magnitude. Synergy persisted in-vivo as single-dose systemic treatment of Klebsiella infected mice resulted in 10-20% versus 60% survival, respectively accomplished by individual and combined compounds. This outcome was achieved without drug formulation, rather, pharmacokinetic considerations have inspired the therapeutic regimen.

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Citations

Nov 3, 2015·Biochimica Et Biophysica Acta·Galoz KanetiAmram Mor
Oct 19, 2016·Current Opinion in Microbiology·Thomas P ZabawaTroy Lister
Mar 23, 2017·The Journal of Infectious Diseases·Joanna JammalAmram Mor
Aug 30, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia MolchanovaHenrik Franzyk
Apr 16, 2019·Critical Reviews in Microbiology·Yuan LiuZhiqiang Wang
Jul 11, 2019·Open Biology·Anne WitzkyMichael Ibba
Jun 1, 2019·FEMS Microbiology Reviews·Mark LawsKhondaker Miraz Rahman
Sep 15, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joanna JammalAmram Mor
Jul 25, 2019·Frontiers in Cellular and Infection Microbiology·Kristin R BakerLuca Guardabassi
May 21, 2017·Scientific Reports·Ohad MeirAmram Mor
Nov 23, 2017·Frontiers in Microbiology·Yesha S Patel, Sarika Mehra
Dec 8, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ningyi ZhuJingman Ni
Sep 12, 2020·Journal of Medicinal Chemistry·Minghui WangJianfeng Cai
Oct 27, 2021·ACS Infectious Diseases·Sreevalli SharmaSantanu Datta
Nov 3, 2021·ACS Applied Materials & Interfaces·Brendan P DyettCharlotte E Conn

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Methods Mentioned

BETA
light-scattering
light scattering

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