PMID: 6406904Jun 9, 1983Paper

Sensitization of Gram-negative bacteria to antibiotics and complement by a nontoxic oligopeptide

Nature
M Vaara, T Vaara

Abstract

A major virulence factor of bacteria that cause generalized infections is their resistance to the lytic action of the complement cascade, an important defence mechanism of the host. Invasive Gram-negative enteric bacteria, which cause about one-third of all bacteraemic infections, are completely resistant to lysis by complement, even in the presence of hyperimmune serum. The same bacteria are also resistant to many antibiotics that are effective therapeutic agents against other bacteria, as the outermost surface layer (the outer membrane) of the bacteria functions as a permeability barrier. Here we show that it is possible to sensitize such bacteria to both complement and antibiotics by using an agent that binds to the outer membrane. This agent is a nontoxic derivative of polymyxin which by itself has no bactericidal action.

References

Dec 11, 1976·Lancet·G T WilliamsS Tabaqchali
Jan 1, 1977·Annual Review of Biochemistry·D R StormP E Swanson
Dec 1, 1977·The Journal of Antibiotics·K S Rosenthal, D R Storm
Sep 1, 1979·Journal of Bacteriology·J PaakkanenP H Mäkelä
Jan 1, 1979·Advances in Microbial Physiology·H Nikaido, T Nakae
Jul 21, 1967·Biochemical and Biophysical Research Communications·L Leive, V Kollin
May 10, 1974·Annals of the New York Academy of Sciences·L Leive
Jan 1, 1970·The Journal of Infectious Diseases·C M Kunin
Dec 1, 1972·Bacteriological Reviews·K E SandersonP H Mäkelä
Jun 1, 1981·The Journal of Antimicrobial Chemotherapy·S P Borriello, H E Larson
Jan 1, 1960·The Journal of Clinical Investigation·R J Roantree, L A Rantz

❮ Previous
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Citations

Oct 25, 1995·Biochimica Et Biophysica Acta·S Y LiaoS H Wu
May 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·Z MalikY Nitzan
Nov 26, 2002·FEMS Microbiology Letters·Paul B SavageQunying Guan
Jan 5, 1999·Bioorganic & Medicinal Chemistry Letters·V SolP Krausz
Oct 31, 2009·Journal of Medicinal Chemistry·Tony VelkovJian Li
Feb 20, 2010·The Journal of Antimicrobial Chemotherapy·Bing ZhaiXiaorong Lin
Mar 18, 2010·The Journal of Antimicrobial Chemotherapy·Carina Vingsbo LundbergMartti Vaara
Feb 16, 2013·The Journal of Antimicrobial Chemotherapy·Martti Vaara
Jul 2, 2008·Antimicrobial Agents and Chemotherapy·Martti VaaraTimo Vaara
Aug 22, 2007·Antimicrobial Agents and Chemotherapy·Mart KrupovicDennis H Bamford
Jun 1, 1984·Antimicrobial Agents and Chemotherapy·P Viljanen, M Vaara
Apr 1, 1985·Antimicrobial Agents and Chemotherapy·M Vaara, P Viljanen
Jul 1, 1985·Antimicrobial Agents and Chemotherapy·H S WarrenG R Siber
Feb 1, 1986·Antimicrobial Agents and Chemotherapy·G Boguslawski
May 1, 1986·Antimicrobial Agents and Chemotherapy·R A Dixon, I Chopra
Sep 1, 1987·Antimicrobial Agents and Chemotherapy·R N McCashion, W H Lynch
Apr 1, 1988·Antimicrobial Agents and Chemotherapy·J S Chapman, N H Georgopapadakou
Sep 1, 1989·Antimicrobial Agents and Chemotherapy·R L DannerJ E Parrillo
Jan 1, 1991·Antimicrobial Agents and Chemotherapy·A YamaguchiT Sawai
Jun 1, 1991·Antimicrobial Agents and Chemotherapy·R P DarveauC S Watkins
Oct 19, 2000·Antimicrobial Agents and Chemotherapy·R DaugelaviciusD H Bamford
Jun 28, 2005·Antimicrobial Agents and Chemotherapy·Toshiaki KotaniTatsuo Yagura
Feb 24, 2006·Antimicrobial Agents and Chemotherapy·Rajalakshmi BalakrishnaSunil A David
Oct 16, 2014·International Journal of Antimicrobial Agents·Stephen A Cochrane, John C Vederas
Jun 1, 1990·Immunität und Infektion·S BhakdiJ Tranum-Jensen
Jun 9, 1983·Nature·H R Perkins
Jan 1, 1986·Critical Reviews in Microbiology·T Nakae
Oct 4, 2012·Expert Review of Anti-infective Therapy·Silpak BiswasJean-Marc Rolain
Nov 4, 2000·Expert Opinion on Investigational Drugs·P B Savage, C Li

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