PMID: 2111312Mar 1, 1990Paper

Sensitization of group III muscle afferents to static contraction by arachidonic acid

Journal of Applied Physiology
D M RottoM P Kaufman

Abstract

The afferent arm of the reflex are responsible for the pressor response to static contraction is comprised of group III and IV fibers. The nature of the contraction-induced stimulus activating these fibers remains unclear. Evidence suggests that most group III afferents are sensitive to mechanical stimuli, whereas most group IV afferents are sensitive to metabolic stimuli. Recently, in anesthetized cats, stimulation of group III mechanoreceptors has been shown to have a role in the reflex pressor response to static contraction. In skin, the sensitivity of thin fiber mechanoreceptors to distortion of their receptive fields has been shown to be increased by both cyclooxygenase and lipoxygenase products of arachidonic acid metabolism. Therefore, in barbiturate-anesthetized cats we recorded the responses of group III muscle afferents to static contraction before and after arachidonic acid (1-2 mg ia) and/or indomethacin (5 mg/kg iv). Arachidonic acid increased the responses of group III afferents (n = 11) to contraction by 265% (from 0.17 +/- 0.07 to 0.62 +/- 0.24 impulses/s; P less than 0.025). Indomethacin decreased the responses of group III afferents (n = 9) to contraction by 61% (from 1.00 +/- 0.37 to 0.39 +/- 0.16 impulses/s;...Continue Reading

Citations

Jun 1, 1997·Journal of Applied Physiology·C M AdreaniM P Kaufman
Feb 6, 1998·Journal of Applied Physiology·S Mostoufi-MoabL I Sinoway
Feb 4, 1999·Journal of Applied Physiology·D I CarrascoC A Ray
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Mar 31, 2007·The Journal of Physiology·Shawn G HayesMarc P Kaufman
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Mar 11, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Afsana MomenLawrence I Sinoway
Aug 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Anna K LealMarc P Kaufman
Nov 8, 2011·Experimental Physiology·Marc P Kaufman
Sep 10, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Javier A Sala-MercadoDonal S O'Leary
Jul 21, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Korynne S RollinsSteven W Copp
Aug 31, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Alec L E ButenasSteven W Copp
Jun 6, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Guillaume P DucrocqMarc P Kaufman
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Jan 10, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Shawn G HayesMarc P Kaufman

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