Sensitization of renal transplant candidates by cryopreserved cadaveric venous or arterial allografts

Transplantation
Mayra Lopez-CeperoVictor Bowers

Abstract

Cryopreserved cadaveric venous or arterial allografts are used in ESRD patients as an alternative to synthetic grafts for hemodialysis access. We evaluated the effect of these allografts on the PRA against HLA class I and II antigens in 11 ESRD patients awaiting a kidney transplant. Flow Cytometry using purified antigen coated beads (Flow PRA Beads) was used to determine PRA against HLA class I and II antigens. Patients with no antibody prior to allograft implantation were all positive for HLA class I and II antibodies after implantation. Patients with anti-HLA class I and II antibodies prior to allografting, developed higher antibody titers. Of the 11 patients that received cryopreserved cadaveric allografts no deaths were reported. Two grafts were removed due to thrombosis consistent with rejection. Recipients of cadaveric venous or arterial allografts elicit an HLA antibody response attesting to the antigenicity of cryopreserved cadaveric allografts.

References

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Citations

Sep 1, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alexander S Goldfarb-RumyantzevAlfred K Cheung
Mar 25, 2005·Pediatric Transplantation·Robert E Shaddy, Thomas C Fuller
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Paul I Terasaki
May 17, 2008·Clinical Transplantation·Hongying TangAlexander S Goldfarb-Rumyantzev
Sep 6, 2013·Seminars in Dialysis·Antonio Inda-FilhoAnna Broder
Mar 13, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Shruti MittalSusan Fuggle
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Dec 18, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·I MatiaM Adamec
Jan 28, 2014·Clinical Kidney Journal·Line M L BoullandMorten H Skauby
Mar 10, 2015·The Journal of Vascular Access·Nicholas G Inston
May 14, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Neetika GargDidier A Mandelbrot
Oct 10, 2020·Science·Laura E Niklason, Jeffrey H Lawson

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