Sensitization of the histamine H1 receptor by increased ligand affinity.

The Journal of Biological Chemistry
S M BloemersS de Laat

Abstract

Histamine regulates a variety of physiological processes including inflammation, gastric acid secretion, and neurotransmission. The cellular response to histamine is subject to dynamic control, and exaggerated histamine reactivity in response to cysteinyl leukotrienes and other stimuli is important in a variety of different pathological conditions. The molecular mechanisms controlling histamine responsiveness are still unresolved. In investigating histamine responses in embryonic stem (ES5) and F9 embryonic carcinoma cells, we encountered a novel mechanism controlling the cellular reaction to histamine. Unstimulated cells displayed neither [3H]pyrilamine binding nor histamine-induced increases in cytosolic Ca2+ levels. Pretreatment of these cells, however, with leukotriene D4, leukotriene E4, serotonin, or fetal calf serum induced an immediate and transient ability of these cells to respond to histamine with an increase in cytosolic Ca2+ levels. This effect could be inhibited by pertussis toxin and was mimicked by GTP analogues. Importantly, the latter compounds also provoked immediate high affinity [3H]pyrilamine binding. We conclude that in these cells histamine responsiveness is directly controlled by pertussis toxin-sensiti...Continue Reading

References

Dec 1, 1992·The American Review of Respiratory Disease·P E ChristieT H Lee
Nov 1, 1991·The American Review of Respiratory Disease·S P O'HickeyT H Lee
Oct 1, 1991·Trends in Biochemical Sciences·K Palczewski, J L Benovic
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M YamashitaH Wada
Apr 1, 1990·The American Review of Respiratory Disease·M G Kaye, L J Smith
Jan 1, 1968·Physiological Reviews·G Kahlson, E Rosengren
May 1, 1995·Journal of Neuroscience Methods·M P PeppelenboschS W De Laat
Jun 1, 1995·Pharmacology & Therapeutics·R LeursH Timmerman
May 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F C Thien, E H Walters
Aug 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T SakuraiH Nagai
Feb 26, 1993·Biochemical and Biophysical Research Communications·S M BloemersS W de Laat
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·M J SmitH Timmerman

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Citations

Sep 30, 1999·Microscopy Research and Technique·G R Van Den BrinkM P Peppelenbosch
Aug 10, 2006·PLoS Biology·Maarten F BijlsmaMaikel P Peppelenbosch
Jun 17, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Peters-GoldenA Togias
May 26, 2017·Journal of Clinical Laboratory Analysis·Yan XiaLi Pang
Apr 18, 2017·Experimental and Therapeutic Medicine·Yuna ChaiZhenwen Qiu

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