Sensitization of the trigeminovascular system following environmental irritant exposure

Cephalalgia : an International Journal of Headache
Phillip Edward KunklerJoyce Harts Hurley

Abstract

Air pollution is linked to increased emergency room visits for headache, and migraine patients frequently cite chemicals or odors as headache triggers, but the association between air pollutants and headache is not well understood. We previously reported that nasal administration of environmental irritants acutely increases meningeal blood flow via a TRPA1-dependent mechanism involving the trigeminovascular system. Here, we examine whether chronic environmental irritant exposure sensitizes the trigeminovascular system. Male rats were exposed to acrolein, a TRPA1 agonist, or room air by inhalation for four days prior to meningeal blood flow measurements. Some animals were injected daily with a TRPA1 antagonist, AP-18, or vehicle prior to inhalation exposure. Trigeminal ganglia were isolated following blood flow measurements for immunocytochemistry and/or qPCR determination of TRPV1, TRPA1 and CGRP levels. Acrolein inhalation exposure potentiated blood flow responses both to TRPA1 and TRPV1 agonists compared to room air. Acrolein exposure did not alter TRPV1 or TRPA1 mRNA levels or TRPV1 or CGRP immunoreactive cell counts in the trigeminal ganglion. Acrolein sensitization of trigeminovascular responses to a TRPA1 agonist was atte...Continue Reading

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Citations

Jun 17, 2016·The Journal of Physiology·Jannis E MeentsPeter A McNaughton
Mar 1, 2016·Cephalalgia : an International Journal of Headache·Raimundo Pereira Silva-NétoMarcelo Moraes Valença
Jun 16, 2016·Cephalalgia : an International Journal of Headache·Balázs MaricsMária Dux
Nov 30, 2018·Journal of Neurophysiology·Jannis E MeentsMichael J M Fischer
Oct 24, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Leslie C ThompsonAimen K Farraj
Feb 21, 2019·Molecular Pain·LuJuan ZhangJoyce Harts Hurley
Nov 2, 2019·Physiological Reviews·Karel TalaveraBernd Nilius
Jul 3, 2020·Cephalalgia : an International Journal of Headache·Anna Koldbro HanstedInger Jansen-Olesen
Sep 2, 2020·Neuroscience Bulletin·Mamoru Shibata, Chunhua Tang
Dec 29, 2017·Neuroscience Bulletin·Carlene MooreWolfgang B Liedtke
Apr 12, 2019·Pharmaceuticals·Silvia Benemei, Greg Dussor
Apr 30, 2020·ACS Chemical Neuroscience·Swapnil RautPallab Bhattacharya

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Methods Mentioned

BETA
PCR

Software Mentioned

Axoscope
ABI PRISM
GraphPad Prism
Photoshop

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