PMID: 2103164Jan 1, 1990Paper

Sensitization to kidney transplants

Clinical Transplants
G W RankinP I Terasaki

Abstract

1. Greater than 50% PRA-sensitized first kidney graft recipients show significantly lower graft survival rates than nonsensitized (0-10% PRA) and moderately sensitized (11-50% PRA) recipients. Most of the effect of sensitization can be seen within the first month posttransplantation. 2. Increases in cellular immunity or antibodies not currently detected by lymphocyte cytotoxicity may account for the decreased graft survival rates in second and multiple graft recipients. One possibility involves the presence of antiplatelet antibodies. 3. Transfusions seem to be the weakest stimulus for sensitization when compared to pregnancy, and to graft failure, which is the strongest. In addition, low numbers of transfusions tend to have a beneficial effect, especially on second kidney graft survival. 4. During the years since the prospective use of the T-cell FCXM by Los Angeles transplant centers, there has been a marked increase in graft survival rates for multiple graft recipients. However, the rates for the sensitized multiple transplant group still remain lower than those for the nonsensitized first and multiple graft groups.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Transplants
J M Cecka, L Cho
Clinical Transplants
K Ogura
Clinical Transplants
S HardyP I Terasaki
© 2021 Meta ULC. All rights reserved