PMID: 15222800Jun 30, 2004Paper

Sensitization to radiation from an implanted 125I source by sustained intratumoral release of chemotherapeutic drugs

Radiation Research
Mohammed BerradaShirley M Lehnert

Abstract

We have investigated tumor response to low-dose-rate irradiation from an implanted 125I source alone or in conjunction with intratumoral drug administration. The drug (cis-DDP or 5-FU) was incorporated homogeneously into the co-polymer CPP-SA, 20:80, and the polymer/drug rods were implanted in the RIF-1 fibrosarcomas growing subcutaneously in C3H mice. Twenty-four hours later, the tumor was implanted with an 125I seed. Tumor growth time was the end point in these experiments. For implanted 125I sources of different dose rates and implant times giving a range of total doses, a consistent dose-response relationship was shown between tumor growth time and total dose. In other experiments, 125I sources of different specific activities were implanted for periods of time adjusted so that the total dose to the tumor was always the same. When the 125I implant was combined with 5-FU, greater than additive responses were seen for both short (30 h) and long (96 h) 125I treatment times. In contrast, a short-duration (30 h) 125I implant combined with cis-DDP was the least effective treatment, giving a combined response that was no better than additive, whereas 96 h exposure to 125I combined with cis-DDP was the most effective combined treat...Continue Reading

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Citations

Jun 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ting LuoQing-Bin Lu
Aug 23, 2005·International Journal of Radiation Oncology, Biology, Physics·Shirley LehnertFrank Verhaegen
Nov 9, 2021·International Journal of Radiation Biology·Shirley Lehnert

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