PMID: 8597435Dec 29, 1995Paper

Sensitization to stress and psychostimulants. Involvement of dopamine transmission versus the HPA axis

Annals of the New York Academy of Sciences
B M PrasadP W Kalivas

Abstract

Rats exposed to chronic stress demonstrate an enhanced motor response to psychostimulants, such as cocaine. This behavioral cross-sensitization between stress (repeated mild footshock) and cocaine (15 mg/kg, ip) is associated with an increase in extracellular dopamine in the nucleus accumbens, but a decrease in the prefrontal cortex. To determine a role for the hypothalamic-pituitary-adrenal axis in sensitization, rats were adrenalectomized prior to administering repeated cocaine injections. One and twelve days after discontinuing repeated cocaine, rats were challenged with acute cocaine. Adrenalectomy blocked the cocaine-induced sensitization observed in sham animals, but both the sham and adrenalectomized rats demonstrated behavioral sensitization to cocaine after twelve days of withdrawal. These data argue that while long-term alterations in dopamine transmission may be an important neurochemical substrate of stress and psychostimulant-induced sensitization, the hypothalamic-pituitary-adrenal axis may not have a necessary role.

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Citations

Oct 19, 2011·Journal of Neural Transmission·Fábio C CruzCleopatra S Planeta
Oct 19, 2002·Behavioural Brain Research·Vera KlenerováSixtus Hynie
Jun 16, 2010·Experimental and Clinical Psychopharmacology·Matthew S HerbertSanders A McDougall
Sep 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Harinder AujlaFriedbert Weiss
Aug 2, 2002·Neuroreport·Marina R PicciottoBarbara J Caldarone
Sep 8, 2010·Journal of Psychopharmacology·Sherry A McKeeJesse Wanzer
Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Herbert E CovingtonEric J Nestler
Jul 10, 2013·Expert Opinion on Drug Metabolism & Toxicology·Maria Konstandi
May 15, 2013·Drug and Alcohol Dependence·Andrew L Eagle, Shane A Perrine
Nov 20, 2009·Bipolar Disorders·David A CousinsAllan H Young
Feb 16, 2000·Molecular Psychiatry·L PaniG L Gessa
Feb 23, 2020·Frontiers in Behavioral Neuroscience·Cristina E María-Ríos, Jonathan D Morrow

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