Sensitization to the neuroendocrine, central monoamine and behavioural effects of murine tumor necrosis factor-alpha: peripheral and central mechanisms

The European Journal of Neuroscience
Shawn HayleyH Anisman

Abstract

Systemic administration of murine tumour necrosis factor-alpha (mTNF-alpha; 0.1-2.0 microg, i.p.) dose-dependently increased plasma corticosterone and augmented monoamine utilization within the paraventricular nucleus of the hypothalamus (PVN), locus coeruleus, medial prefrontal cortex (PFC), central and medial amygdala. A time-dependent sensitization was induced in mice, wherein reexposure to mTNF-alpha 28 days (but not 1 day) following the initial cytokine treatment provoked marked signs of illness (diminished activity, ptosis, piloerection) and increased plasma corticosterone levels. Serotonin (5-HT) activity was augmented upon mTNF-alpha reexposure at the 1- or 28-day intervals in the PFC and medial amygdala, respectively. Intracerebroventricular (i.c.v.; 1-500 ng) mTNF-alpha did not promote illness, but modestly increased plasma corticosterone levels. Neither the illness nor the corticosterone changes were subject to a sensitization upon i.c.v. cytokine reexposure. Acute i.c.v. mTNF-alpha increased norepinephrine (NE), 5-HT and dopamine (DA) activity within the PVN and median eminence/arcuate nucleus complex (ME/ARC), and NE utilization within the central amygdala. Subsequent i.c.v. mTNF-alpha further enhanced the hypothal...Continue Reading

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Citations

May 12, 2005·Neuroscience and Biobehavioral Reviews·Adrian J DunnRenaud de Beaurepaire
Apr 5, 2003·Brain, Behavior, and Immunity·Hymie AnismanShawn Hayley
Jun 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George R BreeseRobert A Angel
Jul 28, 2010·Clinical Neuropharmacology·Francis E LotrichBruce G Pollock
Jun 15, 2011·Brain, Behavior, and Immunity·Urs Meyer
Feb 19, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Christine M TenkKlaus-Peter Ossenkopp
Nov 1, 2008·The European Journal of Neuroscience·Jennifer L Szczytkowski, Donald T Lysle
Aug 26, 2006·Alcoholism, Clinical and Experimental Research·Melissa HermanCatherine Rivier
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Apr 9, 2008·Journal of Psychiatric Research·Ana Raquel MesquitaNuno Sousa
Nov 28, 2006·Behavioural Brain Research·Amanda C KentnerCatherine Bielajew
Jun 7, 2005·Journal of Neurochemistry·Astrid VallèsAntonio Armario
Jul 22, 2004·Behavioural Brain Research·Francis X BrennanRichard J Servatius
Mar 15, 2005·Stress : the International Journal on the Biology of Stress·Antonio ArmarioXavier Belda
Apr 16, 2003·Annals of Medicine·Hymie Anisman, Zul Merali
Nov 6, 2015·Frontiers in Neuroscience·Norbert MüllerMarkus J Schwarz

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