Sensitizing effects of lafutidine on CGRP-containing afferent nerves in the rat stomach

British Journal of Pharmacology
Katsushi NishiharaNaosuke Matsuura

Abstract

1. Capsaicin sensitive afferent nerves play an important role in gastric mucosal defensive mechanisms. Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene-related peptide (CGRP), which seems to be the predominant neurotransmitter of spinal afferents in the rat stomach, exerting many pharmacological effects by a direct mechanism or indirectly through second messengers such as nitric oxide (NO). 2. Lafutidine is a new type of anti-ulcer drug, possessing both an antisecretory effect, exerted via histamine H(2) receptor blockade, and gastroprotective activities. Studies with certain antagonists or chemical deafferentation techniques suggest the gastroprotective actions of lafutidine to be mediated by capsaicin sensitive afferent nerves, but this is an assumption based on indirect techniques. In order to explain the direct relation of lafutidine to afferent nerves, we conducted the following studies. 3. We determined CGRP and NO release from rat stomach and specific [(3)H]-resiniferatoxin (RTX) binding to gastric vanilloid receptor subtype 1 (VR1), which binds capsaicin, using EIA, a microdialysis system and a radioreceptor assay, respectively. 4. Lafutidine enhanced both CGRP and NO release from the rat...Continue Reading

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Citations

Sep 9, 2010·Digestive Diseases and Sciences·Yasutada Akiba, Jonathan D Kaunitz
Feb 19, 2013·Journal of Agricultural and Food Chemistry·Ah Young ChoiHye Sun Gwak
Jan 25, 2003·Journal of Gastroenterology and Hepatology·Masashi YonedaAkira Terano
Feb 27, 2003·Journal of Gastroenterology and Hepatology·Hiroshi Kaneko
Oct 13, 2006·Current Opinion in Gastroenterology·Sushovan Guha, Jonathan D Kaunitz
Apr 17, 2004·Journal of Gastroenterology and Hepatology·Yoshihisa NozawaMamoru Kiniwa
Oct 16, 2010·European Journal of Pharmacology·Xiu-Ju LuoYuan-Jian Li
Nov 3, 2009·European Journal of Pharmacology·Jun Peng, Yuan-Jian Li
Jan 30, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M ToidaT Shibata
Nov 23, 2006·European Journal of Pharmacology·Toshiyuki FunatsuMasao Sasamata
Jun 30, 2005·The Journal of Pharmacology and Experimental Therapeutics·Eitaro AiharaKoji Takeuchi
Jan 19, 2005·Journal of Pharmacological Sciences·Kana KuniedaToshihiko Murayama
Jan 13, 2016·Journal of Complementary & Integrative Medicine·Amal K Maji, Pratim Banerji
Sep 1, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Makoto Tominaga

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