Sensitizing the Tumor Microenvironment to Immune Checkpoint Therapy.

Frontiers in Immunology
Rachael M ZemekW Joost Lesterhuis

Abstract

Immune checkpoint blockade (ICB) has revolutionized cancer treatment, providing remarkable clinical responses in some patients. However, the majority of patients do not respond. It is therefore crucial both to identify predictive biomarkers of response and to increase the response rates to immune checkpoint therapy. In this review we explore the current literature about the predictive characteristics of the tumor microenvironment and discuss therapeutic approaches that aim to change this toward a milieu that is conducive to response. We propose a personalized biomarker-based adaptive approach to immunotherapy, whereby a sensitizing therapy is tailored to the patient's specific tumor microenvironment, followed by on-treatment verification of a change in the targeted biomarker, followed by immune checkpoint therapy. By incorporating detailed knowledge of the immunological tumor microenvironment, we may be able to sensitize currently non-responsive tumors to respond to immune checkpoint therapy.

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Citations

Jul 23, 2020·Frontiers in Oncology·Yuehui LiangFang Xiao
Jul 28, 2020·Frontiers in Immunology·Cai Zhang, Yuxia Liu
Nov 8, 2020·The Journal of Pharmacology and Experimental Therapeutics·Chunxiao LvYanguang Cao
Jan 28, 2021·International Journal of Molecular Sciences·Noel E DonlonJoanne Lysaght
Apr 4, 2021·International Journal of Molecular Sciences·Simone Lipinski, Katharina Tiemann
May 1, 2021·Cancers·Yang ZhaoJennifer Gamble
May 1, 2021·Biomedicines·Melanie A KimmMoritz Wildgruber
May 15, 2021·EMBO Molecular Medicine·Devadarssen MurdamoothooGertraud Orend
Mar 28, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aparna HegdeDavid S Hong
May 26, 2021·Seminars in Cancer Biology·Hong-My NguyenDipongkor Saha
Jun 12, 2021·British Journal of Cancer·Charlotte PilardMichael Herfs
Jul 9, 2021·Frontiers in Cell and Developmental Biology·Chris M Li, Zhibin Chen

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Methods Mentioned

BETA
biopsies
xenograft
RNAseq
biopsy

Clinical Trials Mentioned

NCT02834052
NCT03721679
NCT02643303

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