Sensorimotor dysfunction of grasping in schizophrenia: a side effect of antipsychotic treatment?

Journal of Neurology, Neurosurgery, and Psychiatry
Dennis A NowakM Spitzer

Abstract

Antipsychotic treatment in schizophrenia is frequently associated with extrapyramidal side effects. Objective behavioural measures to evaluate the severity of extrapyramidal side effects in the clinical setting do not exist. This study was designed to investigate grasping movements in five drug naive and 13 medicated subjects with schizophrenia and to compare their performance with that of 18 healthy control subjects. Deficits of grip force performance were correlated with clinical scores of both parkinson-like motor disability and psychiatric symptom severity Participants performed vertical arm movements with a handheld instrumented object and caught a weight that was dropped into a handheld cup either expectedly from the opposite hand or unexpectedly from the experimenter's hand. The scaling of grip force and the temporospatial coupling between grip and load force profiles was analysed. The psychiatric symptom severity was assessed by the positive and negative symptom score of schizophrenia and the brief psychiatric rating scale. Extrapyramidal symptoms were assessed by the unified Parkinson's disease rating scale. Drug naive subjects with schizophrenia performed similar to healthy controls. In contrast, medicated subjects wi...Continue Reading

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Citations

Jun 10, 2015·Cognitive Neuropsychiatry·Yoshiro Nakagawa, Minoru Hoshiyama
Jul 26, 2017·Frontiers in Psychiatry·Maxime TérémetzPåvel G Lindberg

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