Sensorimotor, language, and working memory representation within the human cerebellum

Human Brain Mapping
Reiko AshidaJonathan C W Brooks

Abstract

The cerebellum is involved in a wide range of behaviours. A key organisational principle from animal studies is that somatotopically corresponding sensory input and motor output reside in the same cerebellar cortical areas. However, compelling evidence for a similar arrangement in humans and whether it extends to cognitive functions is lacking. To address this, we applied cerebellar optimised whole-brain functional MRI in 20 healthy subjects. To assess spatial overlap within the sensorimotor and cognitive domains, we recorded activity to a sensory stimulus (vibrotactile) and a motor task; the Sternberg verbal working memory (VWM) task; and a verb generation paradigm. Consistent with animal data, sensory and motor activity overlapped with a somatotopic arrangement in ipsilateral areas of the anterior and posterior cerebellum. During the maintenance phase of the Sternberg task, a positive linear relationship between VWM load and activity was observed in right Lobule VI, extending into Crus I bilaterally. Articulatory movement gave rise to bilateral activity in medial Lobule VI. A conjunction of two independent language tasks localised activity during verb generation in right Lobule VI-Crus I, which overlapped with activity during...Continue Reading

References

Nov 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J WorsleyP Neelin
Jul 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L W Tempel, J S Perlmutter
Jan 31, 1992·Science·A Baddeley
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P T FoxW T Thach
Jul 1, 1985·Archives of Neurology·H L RekateR A Ratcheson
Jul 26, 1971·Experimental Brain Research·J C EcclesH Táboríková
Aug 5, 1966·Science·S Sternberg
Jul 1, 1967·Journal of Neurophysiology·W T Thach
May 13, 1998·Brain : a Journal of Neurology·J D Schmahmann, J C Sherman
Jul 13, 1999·Journal of Neurophysiology·R A WeeksM Hallett
Jan 5, 2000·Neuroreport·M RijntjesC Weiller
Nov 4, 2000·Trends in Cognitive Sciences·A Baddeley
Nov 15, 2001·NeuroImage·M W WoolrichS M Smith
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mark A GriswoldAxel Haase
Nov 8, 2002·The Quarterly Journal of Experimental Psychology. A, Human Experimental Psychology·Kathleen RastleMax Coltheart
Jan 2, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mark Jenkinson
May 14, 2003·Journal of Communication Disorders·Alan Baddeley
Mar 17, 2004·Brain Research. Cognitive Brain Research·Aimee J NelsonWilliam E McIlroy
Oct 16, 2004·Human Brain Mapping·Andreas JansenStefan Knecht
Oct 30, 2004·Brain Research. Cognitive Brain Research·Tara A CairoElton T C Ngan
Apr 6, 2005·NeuroImage·Thomas NicholsJean-Baptiste Poline
Jun 14, 2005·Neuropsychologia·S H Annabel Chen, John E Desmond
Dec 6, 2005·Neuroscience·C Jarrold, J N Towse
Mar 1, 2006·Somatosensory & Motor Research·Miyuki Morioka, Michael J Griffin
Oct 19, 2006·Neuroscience Letters·Markus FringsDagmar Timmann
Nov 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Angelique PijpersTom J H Ruigrok
Mar 16, 2007·Medical Image Computing and Computer-assisted Intervention : MICCAI·Günther GrabnerD Louis Collins
Apr 5, 2007·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Eleni KapreliStefan Sunaert
May 2, 2007·Journal of Experimental Psychology. Learning, Memory, and Cognition·Michael J KaneGregory J H Colflesh
Oct 24, 2007·NeuroImage·Jonathan C W BrooksMark Jenkinson
Aug 16, 2008·Journal of Cognitive Neuroscience·Ferath KherifCathy J Price
Oct 7, 2008·NeuroImage·Catherine J Stoodley, Jeremy D Schmahmann

❮ Previous
Next ❯

Citations

Sep 22, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G PontilloM Quarantelli

❮ Previous
Next ❯

Software Mentioned

Presentation
FMRIB
FSL
VBM8
FEAT
SPM
GRAPPA
AUTOAQ
FEAT ( FMRIB Expert Analysis Tool

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.