Sensorimotor neural dynamics during isochronous tapping in the medial premotor cortex of the macaque

The European Journal of Neuroscience
Hugo MerchantLuis Prado

Abstract

We determined the response properties of neurons in the primate medial premotor cortex that were classified as sensory or motor during isochronous tapping to a visual or auditory metronome, using different target intervals and three sequential elements in the task. The cell classification was based on a warping transformation, which determined whether the cell activity was statistically aligned to sensory or motor events, finding a large proportion of cells classified as sensory or motor. Two distinctive clusters of sensory cells were observed, i.e. one cell population with short response-onset latencies to the previous stimulus, and another that was probably predicting the occurrence of the next stimuli. These cells were called sensory-driven and stimulus-predicting neurons, respectively. Sensory-driven neurons showed a clear bias towards the visual modality and were more responsive to the first stimulus, with a decrease in activity for the following sequential elements of the metronome. In contrast, stimulus-predicting neurons were bimodal and showed similar response profiles across serial-order elements. Motor cells showed a consecutive activity onset across discrete neural ensembles, generating a rapid succession of activat...Continue Reading

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Citations

Dec 5, 2015·Frontiers in Systems Neuroscience·Edward W LargeMarc J Velasco
Jul 12, 2016·NeuroImage·Sylvie NozaradanAlexandre Lehmann
Sep 8, 2016·Frontiers in Neuroscience·Sundeep Teki, Tadeusz W Kononowicz
Mar 11, 2017·Frontiers in Psychology·Daya S Gupta, Hugo Merchant
Apr 2, 2017·Journal of Neural Transmission·Hugo Merchant, Ramón Bartolo
Mar 16, 2018·Annals of the New York Academy of Sciences·Henkjan Honing
Jun 28, 2019·American Journal of Primatology·Shahab A ZareiFarshad A Mansouri
Jul 25, 2017·Scientific Reports·Ryuji TakeyaMasaki Tanaka
May 1, 2018·Annals of the New York Academy of Sciences·Jorge GámezHugo Merchant
Jan 10, 2017·Frontiers in Human Neuroscience·Rolf VerlegerKamila Śmigasiewicz
Nov 8, 2019·ELife·Anja PflugChristian Alexander Kell
Aug 7, 2020·Brain Sciences·Naho Konoike, Katsuki Nakamura
Dec 24, 2020·Trends in Cognitive Sciences·Jonathan J Cannon, Aniruddh D Patel
Jun 3, 2021·International Journal of Molecular Sciences·Livia BeccaceceDonata Luiselli
Aug 24, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tomas LencSylvie Nozaradan
Sep 17, 2019·NeuroImage·Petri ToiviainenVinoo Alluri

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