Sensory and Motor Behavior Evidences Supporting the Usefulness of Conditioned Medium from Dental Pulp-Derived Stem Cells in Spinal Cord Injury in Rats

Asian Spine Journal
Reza Asadi-GolshanFarzaneh Dehghani

Abstract

Experimental animal study. This study aimed to assess effects of conditioned medium (CM) of dental pulp-derived stem cells loaded in collagen hydrogel on functional recovery following spinal cord injury (SCI). SCI affects sensory and motor functions, and behavioral recovery is the most essential purpose of therapeutic intervention. Recent studies have reported that CM from dental pulp-derived stem cells has therapeutic benefits. In addition, collagen hydrogel acts as a drug delivery system in SCI experiments. Stem cells from human exfoliated deciduous teeth (SHEDs) were cultured, and SHED-CM was harvested and concentrated. Collagen hydrogel containing SHED-CM was prepared. The rats were divided into five groups receiving laminectomy, compressive SCI with or without intraspinal injection of biomaterials (SHED-CM), and collagen hydrogel with or without SHED-CM. Basso, Beattie, and Bresnahan (BBB) scoring, inclined plane, cold allodynia, and beam walk tests were performed for 6 weeks to assess locomotor, motor, sensory, and sensory-motor performances, respectively. Scores of the rats receiving SHED-CM loaded in collagen hydrogel were significantly better than those of the other injured groups at 1-week post-injury for BBB, 2 weeks...Continue Reading

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Citations

Jul 10, 2019·Molecular & Cellular Proteomics : MCP·Filip HumenikMichel Salzet
Feb 15, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Jian KangGuanghui Xu
Oct 28, 2019·Current Stem Cell Research & Therapy·Chih-Sheng KoWen-Ta Su
Apr 22, 2019·Neurochemical Research·Dasa CizkovaMichel Salzet
Feb 25, 2020·Stem Cells International·Sara El MoshyKarim M Fawzy El-Sayed
Jul 15, 2020·Biology·Shinichiro YoshidaHidefumi Maeda
Sep 1, 2019·Molecular & Cellular Proteomics : MCP·Filip HumenikMichel Salzet
Jul 24, 2021·Frontiers in Cell and Developmental Biology·Eva SykovaSarka Kubinova

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