Sensory Effects of Menthol and Nicotine in an E-Cigarette

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Kathryn Rosbrook, Barry G Green

Abstract

Despite the longstanding use and popularity of menthol as a flavorant in tobacco products, its sensory interactions with inhaled nicotine have never been measured independently of the other irritants in tobacco smoke. We therefore measured the perception of menthol in an E-cigarette with the primary goal of assessing its analgesic effect on the sensory irritation produced by inhaled nicotine. Adult cigarette smokers sampled aerosolized E-liquids containing five different concentrations of nicotine with 0%, 0.5%, or 3.5% l-menthol, as well as two commercial menthol flavors with and without nicotine. For each of the E-liquids participants used a labeled magnitude scale to rate the Overall Sensation intensity, Coolness/Cold, and Irritation/Harshness they experienced, and a Labeled Hedonic Scale to indicate how much they liked/disliked the overall flavor. The main findings were that (1) perceived Irritation/Harshness was unaffected by a low (0.5%) menthol concentration, whereas a high menthol concentration (3.5%) led to higher perceived Irritation/Harshness at low nicotine concentrations but to lower Irritation/Harshness at the highest nicotine concentration (24mg/ml); (2) a commercial Menthol-Mint flavor produced similar results; ...Continue Reading

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Citations

May 29, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Marcus Munafò
Nov 1, 2016·Tobacco Control·Hyoshin KimPamela I Clark
May 2, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Stephen R BaldassarriIrina Esterlis
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May 23, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Erna J Z KrüsemannReinskje Talhout
May 27, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Sabrina L SmileyJennifer L Pearson
Feb 12, 2020·Critical Reviews in Toxicology·Irene YangJeannie Rodriguez
Apr 18, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Elise E DeVitoMehmet Sofuoglu
Apr 19, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Alexa J PullicinJuyun Lim
Sep 25, 2017·Frontiers in Physiology·Eva Ø HansenShellie A Boudreau
Aug 23, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Erna J Z KrüsemannSanne Boesveldt
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Oct 14, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Allison N BakerJohn E Hayes
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Nov 28, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Samane Zare, Yuqing Zheng
Feb 1, 2021·Addictive Behaviors·Joshua L Karelitz, Kenneth A Perkins
Dec 11, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Raina D PangAdam M Leventhal

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