Sensory-Evoked Spiking Behavior Emerges via an Experience-Dependent Plasticity Mechanism

Neuron
Joram J van RheedeColin J Akerman

Abstract

The ability to generate action potentials (spikes) in response to synaptic input determines whether a neuron participates in information processing. How a developing neuron becomes an active participant in a circuit or whether this process is activity dependent is not known, especially as spike-dependent plasticity mechanisms would not be available to non-spiking neurons. Here we use the optic tectum of awake Xenopus laevis tadpoles to determine how a neuron becomes able to generate sensory-driven spikes in vivo. At the onset of vision, many tectal neurons do not exhibit visual spiking behavior, despite being intrinsically excitable and receiving visuotopically organized synaptic inputs. However, a brief period of visual stimulation can drive these neurons to start generating stimulus-driven spikes. This conversion relies upon a selective increase in glutamatergic input and requires depolarizing GABAergic transmission and NMDA receptor activation. This permissive form of experience-dependent plasticity enables a neuron to start contributing to circuit function.

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Citations

Sep 4, 2015·Neuron·Philip KesnerEdward S Ruthazer
Aug 1, 2016·Current Opinion in Neurobiology·Zhenyu LiuKara G Pratt
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Feb 8, 2021·Neuroscience and Biobehavioral Reviews·Carlijn Peerboom, Corette J Wierenga
Mar 31, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jürgen GrafKnut Kirmse

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