Sensory experience-dependent formation of perineuronal nets and expression of Cat-315 immunoreactive components in the mouse somatosensory cortex

Neuroscience
Hiroshi UenoTakeshi Ishihara

Abstract

Perineuronal nets (PNNs) are structures of extracellular matrix molecules surrounding the cell bodies and proximal dendrites of certain neurons. While PNNs are present throughout the mouse cerebral cortex, recent studies have shown that the components differ among cortical sub-regions and layers, suggesting region-specific functions. Parvalbumin-expressing interneurons (PV neurons) may be important regulators of cortical plasticity during the early "critical period" that is sensitive to sensory input. Here we examined the distribution and developmental functions of PNN components associated with PV neurons in the somatosensory cortex during the critical period. Aggrecan, brevican, neurocan, phosphacan, and tenascin-R were identified as PNN components in the mouse somatosensory cortex. High-magnification analysis revealed that some lectin Wisteria floribunda agglutinin (WFA)-reactive molecules did not co-localize with monoclonal antibody Cat-315 recognition molecules around the cell body. During postnatal development, Cat-315-positive (Cat-315+) PNNs appeared later than PNNs binding to the lectin WFA (WFA+ PNNs). These WFA+ PNNs changed from granular-like to reticular-like structures during normal cortical development, while thi...Continue Reading

Citations

Jul 16, 2017·Biochimica Et Biophysica Acta. General Subjects·Jyoji MoriseShogo Oka
Apr 13, 2018·International Journal of Molecular Sciences·Sian F Irvine, Jessica C F Kwok
Apr 10, 2018·Experimental & Molecular Medicine·Se-Young Choi
Oct 17, 2018·Journal of Neurochemistry·Ubadah SabbaghMichael A Fox
Aug 23, 2020·International Journal of Molecular Sciences·Alec Peters, Larry S Sherman
Aug 21, 2018·Frontiers in Molecular Neuroscience·Teresa H WenKhaleel A Razak
Jan 1, 2018·Trends in Genetics : TIG·Amy W LasekWei-Yang Chen
Mar 7, 2021·International Journal of Molecular Sciences·Daniela Carulli, Joost Verhaagen
Apr 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Vijendra SharmaArkady Khoutorsky
Jul 7, 2021·The Journal of Clinical Investigation·Kelly E CarstensSerena M Dudek
Jan 7, 2022·Movement Disorders : Official Journal of the Movement Disorder Society·Dhananjay YellajoshyulaWilliam T Dauer

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