PMID: 3766152Jul 1, 1986Paper

Sensory irritation and pulmonary irritation of cumene and n-propanol: mechanisms of receptor activation and desensitization

Acta Pharmacologica Et Toxicologica
U KristiansenE Holst

Abstract

Cumene and n-propanol, model substances for alcohols and alkylbenzenes, were investigated for sensory irritation in mice. The concentrations within the first 2 min. depressing the respiratory rate by 50% due to the effect in the upper respiratory tract were 2,058 p.p.m. and 22,080 p.p.m., respectively. Activation of the sensory irritant receptor followed the dynamics of reversible bimolecular reactions. The extrapolated maximum response and the apparent dissociation constant were 114.3% and 2,723 p.p.m. for cumene and 68.4% and 8,178 p.p.m. for propanol, respectively. Later on desensitization was observed. The effect was weak for cumene but conspicuous for propanol. For cumene desensitization had the origin in the rise of a threshold. No change in the dissociation constant or the maximum response was found. For propanol a decrease in the maximum response, which may be explained by an allosteric effect, was observed. The pulmonary irritation response was weak for cumene but was for propanol more important than sensory irritation at high concentrations. The following hypotheses are put forward: the effect of pulmonary irritation on the tidal volume is mediated via the stretch receptors while the effect on the respiratory frequenc...Continue Reading

References

Apr 1, 1978·American Industrial Hygiene Association Journal·L E Kane, Y Alarie
Feb 1, 1985·Acta Pharmacologica Et Toxicologica·G D NielsenE Holst
Feb 1, 1985·Acta Pharmacologica Et Toxicologica·G D NielsenE Holst
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Jul 1, 1951·The Journal of General Physiology·L B KIRSCHNER, W E STONE

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Citations

Jan 1, 1991·Critical Reviews in Toxicology·P M BosP C Bragt
Dec 28, 2000·Human & Experimental Toxicology·S T LarsenG D Nielsen
Jan 1, 1991·Critical Reviews in Toxicology·G D Nielsen
Jan 1, 1988·Archives of Toxicology·U Kristiansen, G D Nielsen
Jan 1, 1988·Archives of Toxicology·U KristiansenG D Nielsen
Sep 1, 1992·Pharmacology & Toxicology·L F HansenG D Nielsen

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