PMID: 7544339May 1, 1995Paper

Sensory nerve- and neuropeptide-mediated relaxation responses in airways of Sprague-Dawley rats

Journal of Applied Physiology
J L SzarekC Schneider

Abstract

We examined the role of sensory nerves in mediating nonadrenergic inhibitory responses in airway segments isolated from male Sprague-Dawley rats. In the presence of adrenergic blockade, capsaicin (Cap; 1 microM) elicited marked relaxation responses in isolated bronchi precontracted with bethanechol (Beth). Cap-induced inhibitory responses were unaffected by tetrodotoxin (TTX), were attenuated by incubation of the airway with indomethacin (Indo), phosphoramidon, or RP-67580, but were abolished by previous exposure of the airway to Cap and by denuding the epithelium. Substance P (SP; 1 microM), neurokinins A and B (1 microM), and calcitonin gene-related peptide (0.1 microM) relaxed Beth-contracted airway segments to a similar extent. The SP-induced responses were unaffected by adrenergic blockade or by pretreatment with either TTX, phosphoramidon, or Cap, but were attenuated by RP-67580 and abolished by Indo and by denuding the epithelium. In anesthetized mechanically ventilated rats, Cap (50 and 100 micrograms/kg i.v.) elicited a dose-dependent reversal of the increase in lung resistance induced by an infusion of Beth. The Cap-induced bronchodilation was unaffected by pretreatment with propranolol alone or in combination with he...Continue Reading

Citations

Dec 31, 1997·The American Journal of Physiology·F X ZhuN E Robinson
Feb 26, 1998·American Journal of Respiratory Cell and Molecular Biology·G W HoyleM Friedman
Jan 14, 1999·The American Journal of Physiology·M J MhannaR J Martin
May 15, 2001·American Journal of Respiratory Cell and Molecular Biology·M J MhannaM A Haxhiu
Nov 9, 2011·The Journal of Pharmacology and Experimental Therapeutics·Samuel J TaylorPeter J Henry
Aug 5, 2011·Canadian Journal of Physiology and Pharmacology·Tamer Y El MaysFrancis H Y Green
Feb 10, 2004·Journal of Applied Physiology·Maroun J MhannaRichard J Martin
May 27, 2006·Journal of Applied Physiology·Brendan J Canning
Jan 17, 2017·Cell and Tissue Research·Katrin Julia AudritChristina Nassenstein
Nov 14, 1998·The American Journal of Physiology·J L SzarekS Lemke
Jul 1, 2007·Current Therapeutic Research, Clinical and Experimental·Maroun J MhannaRobert C Cohn
Feb 25, 2014·Biochemical Pharmacology·Esther Y CheahPeter J Henry
May 9, 2008·Pulmonary Pharmacology & Therapeutics·Brendan J Canning, Yangling Chou

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