Sensory nerve pathology in multifocal motor neuropathy

Annals of Neurology
A M CorseJ W Griffin

Abstract

The nosological status of multifocal motor neuropathy remains controversial. The clinical and electrodiagnostic hallmarks suggest selective motor fiber involvement. In this study, we asked to what extent sensory nerves might be involved pathologically in multifocal motor neuropathy. Examination of sensory nerve biopsy specimens from 11 patients did reveal pathological findings in all, but they were very mild. An increased number of thinly myelinated, large-caliber fibers was the unifying feature common to each specimen. By electron microscopy, each biopsy specimen had thinly myelinated fibers surrounded by minor onion bulbs. Active demyelination, though scant, was seen in 3 nerves. Myelinated fiber density was normal. Subperineurial edema and inflammation were not present. We conclude that multifocal motor neuropathy is not an exclusively motor abnormality, although it appears to be so clinically and electrophysiologically. The frequent, albeit mild, pathological abnormalities in sensory fibers suggest that the demyelinating pathophysiology also affects sensory fibers, but to a lesser degree than motor fibers. Some investigators maintain that multifocal motor neuropathy is within the spectrum of chronic inflammatory demyelinati...Continue Reading

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Citations

Feb 18, 1998·Muscle & Nerve·A S Pakiam, G J Parry
Dec 5, 2000·Muscle & Nerve·K Boonyapisit, B Katirji
Nov 27, 2002·Muscle & Nerve·Cecilia Cappelen-SmithDavid Burke
Nov 13, 2004·Muscle & Nerve·Annie VerschuerenJean Pouget
Aug 10, 2000·Italian Journal of Neurological Sciences·G Comi, L Roveri
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Aug 9, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Fumitaka ShimizuTakashi Kanda
Apr 5, 2014·Journal of Clinical Immunology·Carol Lee Koski
Jul 2, 2014·Nature Reviews. Neurology·Norman Latov
Jun 30, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Suraj Ashok Muley, Gareth J Parry
Apr 30, 2013·Muscle & Nerve·Antonino UnciniMargherita Capasso
Aug 1, 2012·Head & Neck·Aron AltorjayAnna Szilágyi
Oct 7, 2015·Muscle & Nerve·Nurcan ÜçeylerClaudia Sommer
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Nov 10, 2021·Expert Review of Clinical Immunology·Norman Latov

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