Sensory neural hearing loss in beta-thalassemia major patients treated with deferoxamine

Pediatric Hematology and Oncology
Bibi Shahin ShamsianReyhaneh Amini

Abstract

This study evaluated the incidence of sensory neural hearing loss (SNHL) in beta-thalassemia major patients treated with deferoxamine in Mofid Children's Hospital. Based on the patients' file review, this descriptive and cross-sectional study was performed in all thalassemia patients older than 5 years old who were treated with regular blood transfusion and deferoxamine pump injection during the year 2006. The first visit with the otolaryngologist was performed in all patients to demarcate the presence of cerumen, otitis, and congenital abnormalities of ears. Then pure tone audiometery in frequency ranges of 250-8000 Hz was performed. Data statistical analysis was done by Mann-Whitney, chi square, and Fisher tests. There were 67 patients over 5 years old in our study. Five patients (7.4%), including 2 boys and 3 girls, in the age range of 7-24 years (mean:17.8 +/- 6.6 years) had SNHL. Their hearing loss was bilateral and in the frequency range of 2000-4000 Hz, with a mean of 3200 +/- 836.66 Hz. There were no significant differences between SNHL and non-SNHL patients in age, sex, serum ferritin level, age of the first transfusion, starting age of deferoxamine infusion, or duration and dosage of deferoxamine therapy. It seems tha...Continue Reading

References

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Feb 1, 1996·Journal of Pediatric Hematology/oncology·L A Styles, E P Vichinsky
Oct 12, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·U AmbrosettiM D Cappellini
Dec 14, 2005·Journal of Pediatric Hematology/oncology·Shu-Huey ChenHsi-Che Liu

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Citations

Sep 21, 2018·Cochlear Implants International·Tanmaya KatariaMan Prakash Sharma
Nov 10, 2017·Ear, Nose, & Throat Journal·Serhan DerinHatice Topal
May 31, 2019·Ear, Nose, & Throat Journal·Serhan DerinHatice Topal

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