Sensory neural responses to ozone exposure during early postnatal development in rat airways.

American Journal of Respiratory Cell and Molecular Biology
Dawn D HunterRichard D Dey

Abstract

Airway infections or irritant exposures during early postnatal periods may contribute to the onset of childhood asthma. The purpose of this study was to examine critical periods of postnatal airway development during which ozone (O(3)) exposure leads to heightened neural responses. Rats were exposed to O(3) (2 ppm) or filtered air for 1 hour on specific postnatal days (PDs) between PD1 and PD29, and killed 24 hours after exposure. In a second experiment, rats were exposed to O(3) on PD2-PD6, inside a proposed critical period of development, or on PD19-PD23, outside the critical period. Both groups were re-exposed to O(3) on PD28, and killed 24 hours later. Airways were removed, fixed, and prepared for substance P (SP) immunocytochemistry. SP nerve fiber density (NFD) in control extrapulmonary (EXP) epithelium/lamina propria (EPLP) increased threefold, from 1% to 3.3% from PD1-PD3 through PD13-PD15, and maintained through PD29. Upon O(3) exposure, SP-NFD in EXP-smooth muscle (SM) and intrapulmonary (INT)-SM increased at least twofold at PD1-PD3 through PD13-PD15 in comparison to air exposure. No change was observed at PD21-PD22 or PD28-PD29. In critical period studies, SP-NFD in the INT-SM and EXP-SM of the PD2-PD6 O(3) group re...Continue Reading

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Citations

Dec 6, 2011·Toxicological and Environmental Chemistry·Leor C ZellnerRichard D Dey
Feb 21, 2013·Current Opinion in Pediatrics·Rosalind J Wright, Kelly J Brunst
Oct 18, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Z-X WuR D Dey
Feb 22, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tinamarie LieuBradley J Undem
Nov 16, 2010·American Journal of Respiratory Cell and Molecular Biology·Dawn D HunterRichard D Dey
Nov 5, 2011·American Journal of Respiratory Cell and Molecular Biology·Richard L AutenW Michael Foster
Jun 22, 2014·International Immunopharmacology·Jonathan M GaffinWanda Phipatanakul
Oct 14, 2014·International Immunopharmacology·Jonathan M GaffinWanda Phipatanakul
Feb 1, 2011·Biochimica Et Biophysica Acta·Richard L Auten, W Michael Foster
Feb 23, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yaping ZhangCang-Bao Xu
Jun 6, 2019·Physiology·L E M Kistemaker, Y S Prakash
Feb 23, 2013·Epidemiology·Guang-Hui DongEdwin Trevathan
Jun 18, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kruti R PatelXingbin Ai

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