Sensory neurobiological analysis of neuropeptide modulation of meal size

Physiology & Behavior
Gary J Schwartz, Anthony V Azzara

Abstract

Gerry Smith's emphasis on the meal as the functional unit of ingestion spurred experiments designed to (1) identify oral and postoral stimuli that affect meal size, and (2) identify peripheral and central neural mechanisms involved in the processing of sensory signals generated by these stimuli. His observations that gut-brain peptides can limit meal size were important in formulating the idea that neuropeptides involved in the control of food intake modulate the peripheral and central neural processing of meal-stimulated sensory signals. This focus on meal size continues to foster the development of hypotheses and the design of experiments that characterize the sites and modes of action of feeding modulatory neuropeptides. These investigations have focused attention on the gut-brain neuraxis as a critical sensory pathway in the control of ingestive behavior, and have revealed important integrative properties of peripheral and central neurons along this axis. The neuromodulatory function of peptides that alter food intake is supported by their ability to recruit the activation of neurons at multiple central nodes of the gut-brain axis and to affect the neural processing and behavioral potency of meal-related gastrointestinal si...Continue Reading

References

Apr 1, 1977·Physiology & Behavior·E E Becker, J A Grinker
Apr 1, 1987·Appetite·A J Strohmayer, G P Smith
Sep 1, 1973·Journal of Comparative and Physiological Psychology·J GibbsG P Smith
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·G P Smith
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·M D BarrachinaY Taché
Dec 6, 1997·Nature·R J SeeleyM W Schwartz
Sep 2, 1998·Nature·A BadoM J Lewin
Jun 27, 2000·The Journal of Comparative Neurology·C F EliasJ K Elmquist
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M M HaganR J Seeley
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J E McMinnM W Schwartz
Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·K KawaiY Ninomiya
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·L Ste MarieR D Palmiter
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J GlatzleT T Zittel
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S BiT H Moran
Feb 19, 2002·Neuroscience Letters·Christian PeiserRudolf E Lang
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Huiyuan ZhengHans-Rudolf Berthoud
Aug 24, 2002·Endocrinology·Toru HosoiYasuyuki Nomura
Sep 3, 2002·The Journal of Physiology·Stéphanie GaigéMichel Bouvier
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·I SwartT A Houpt
Mar 21, 2003·The New England Journal of Medicine·I Sadaf FarooqiStephen O'Rahilly
Mar 21, 2003·The New England Journal of Medicine·Ruth BransonFritz F Horber

❮ Previous
Next ❯

Citations

Feb 16, 2005·The Journal of Clinical Investigation·Gregory J MortonMichael W Schwartz
Mar 22, 2006·Physiology & Behavior·Thomas V GetchellMarilyn L Getchell
Jun 28, 2005·Peptides·Wei FanShaun F Morrison

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.